Urine metabolomics using liquid chromatography quadrupole time-of-flight mass spectrometry indicates common markers of disease in alkaptonuria and idiopathic.

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Urine metabolomics using liquid chromatography quadrupole time-of-flight mass spectrometry indicates common markers of disease in alkaptonuria and idiopathic osteoarthritis in human B. Norman, A. Davison, P. Wilson, G. Ross, A. Milan, N. Roberts, L. Ranganath, J. Gallagher Osteoarthritis and Cartilage Volume 25, Pages S97-S98 (April 2017) DOI: 10.1016/j.joca.2017.02.156 Copyright © 2017 Terms and Conditions

Figure 1 A&B: Profile plots for all entities across AKU, iOA and healthy sample groups. Each line corresponds to the signal for one entity across individual samples, with red and blue representing up and down-regulated states respectively. A: Positive ESI, B: Negative ESI. Plots show the overlap between the global metabolite profiles in AKU and iOA compared with controls. C&D: PCA plots, displaying the clustering of sample groups. C: Positive ESI. D: Negative ESI. Osteoarthritis and Cartilage 2017 25, S97-S98DOI: (10.1016/j.joca.2017.02.156) Copyright © 2017 Terms and Conditions