CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma Vipul V. Jain, MDa, Kunihiko Kitagaki, PhDa, Thomas Businga,

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CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma Vipul V. Jain, MDa, Kunihiko Kitagaki, PhDa, Thomas Businga, MSa, Iftikhar Hussain, MDa, Caroline George, MDb, Patrick O'Shaughnessy, PhDc, Joel N. Kline, MDa,c Journal of Allergy and Clinical Immunology Volume 110, Issue 6, Pages 867-872 (December 2002) DOI: 10.1067/mai.2002.129371 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 CpG-ODNs prevent eosinophilic airway inflammation, nonspecific bronchial hyperresponsiveness, and antigen-specific IgE induction in a murine model of chronic asthma. Repeated inhalation of OVA in sensitized mice leads to induction of significant BAL fluid eosinophilia (A) , OVA-specific IgE (B) , and bronchial hyperresponsiveness (C) to inhaled methacholine (25 mg/mL), all of which are significantly reduced in mice treated with CpG-ODNs at the time of sensitization. *P < .05 and **P < .001, OVA versus all other groups. Journal of Allergy and Clinical Immunology 2002 110, 867-872DOI: (10.1067/mai.2002.129371) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 CpG-ODNs prevent peribronchial inflammation, subepithelial collagen deposition, and GC hyperplasia-metaplasia in a murine model of chronic asthma. Repeated inhalation of OVA in sensitized mice leads to significant chronic peribronchial inflammation characterized by eosinophil infiltration (A ; hematoxylin and eosin staining) and airway remodeling characterized by subepithelial collagen deposition (B and C ; Masson Trichrome staining) and GC hyperplasia-metaplasia (D ; ABPAS staining), all of which are significantly reduced in mice treated with CpG-ODNs at the time of sensitization (E-H) . Journal of Allergy and Clinical Immunology 2002 110, 867-872DOI: (10.1067/mai.2002.129371) Copyright © 2002 Mosby, Inc. Terms and Conditions