Fig. 7 pDCs are critical for the maintenance of skin fibrosis and for the presence of CXCL4 in the skin. pDCs are critical for the maintenance of skin.

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Fig. 7 pDCs are critical for the maintenance of skin fibrosis and for the presence of CXCL4 in the skin. pDCs are critical for the maintenance of skin fibrosis and for the presence of CXCL4 in the skin. Fibrosis was induced by injection of BLM in WT mice for either 3 or 5 weeks (wks) or in CLEC4C-DTR mice for 5 weeks as described in Materials and Methods. At 3 weeks of BLM treatment, pDC depletion was achieved in CLEC4C-DTR mice by DT injection (in red) while fibrosis induction was sustained for 2 more weeks. (A) Average of skin thickness and (B) of the number of Siglec-H+ cells in the skin. (C) Representative images of the cxcl4 transcript by RNA in situ hybridization (brown signal; original magnification, ×400; inset, ×630) and (D) average of the number of CXCL4+ cells. Experiment was performed twice (n = 4 to 10 per group). All results are represented as means ± SEM, and statistical significance was evaluated using a Mann-Whitney U test. *P < 0.05, **P < 0.01, ***P < 0.001. Marie Dominique Ah Kioon et al., Sci Transl Med 2018;10:eaam8458 Published by AAAS