Multiple Electrode Whole-Blood Aggregometry and Bleeding in Cardiac Surgery Patients Receiving Thienopyridines Marco Ranucci, MD, Ekaterina Baryshnikova,

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Multiple Electrode Whole-Blood Aggregometry and Bleeding in Cardiac Surgery Patients Receiving Thienopyridines Marco Ranucci, MD, Ekaterina Baryshnikova, PhD, Giorgio Soro, MD, Andrea Ballotta, MD, FCCP, Donatella De Benedetti, MD, Daniela Conti, MD The Annals of Thoracic Surgery Volume 91, Issue 1, Pages 123-129 (January 2011) DOI: 10.1016/j.athoracsur.2010.09.022 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Graph analysis (nonlinear regression) for the association of the adenosine diphosphate (ADP) test and postoperative bleeding. The Annals of Thoracic Surgery 2011 91, 123-129DOI: (10.1016/j.athoracsur.2010.09.022) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Receiver operating characteristic curve analysis for excessive bleeding prediction by the ADP test. The best predictive value corresponds to an ADP value of 307 (sensitivity 72%, specificity 66%). (ADP = adenosine diphosphate; AUC= area under the curve; c.i. = confidence interval.) The Annals of Thoracic Surgery 2011 91, 123-129DOI: (10.1016/j.athoracsur.2010.09.022) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Adenosine diphosphate (ADP) test pattern distribution in the study population. The ADP values of 14 patients with excessive bleeding (•) are reported in the upper panel. Ten out of 14 patients with major bleeding have an area under the curve less than 307. The Annals of Thoracic Surgery 2011 91, 123-129DOI: (10.1016/j.athoracsur.2010.09.022) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions