Whole genome sequencing as a tool to investigate a cluster of seven cases of listeriosis in Austria and Germany, 2011–2013 D. Schmid, F. Allerberger,

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Presentation transcript:

Whole genome sequencing as a tool to investigate a cluster of seven cases of listeriosis in Austria and Germany, 2011–2013 D. Schmid, F. Allerberger, S. Huhulescu, A. Pietzka, C. Amar, S. Kleta, R. Prager, K. Preußel, E. Aichinger, A. Mellmann Clinical Microbiology and Infection Volume 20, Issue 5, Pages 431-436 (May 2014) DOI: 10.1111/1469-0691.12638 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Cases of invasive listeriosis caused by Listeria monocytogenes (L.m.)serovar 1/2b by calendar week of diagnosis (Austria, 2010 to February 2014). Clinical Microbiology and Infection 2014 20, 431-436DOI: (10.1111/1469-0691.12638) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Phylogenetic relationships of 18 Listeria monocytogenes serovar 1/2b isolates from different sources based on whole genome sequencing. The minimum spanning tree is based on allelic profiles of 2998 genes present in all strains investigated. Each circle represents a given allelic profile, and contains the isolate's name as given in Materials and Methods. The different sample origin (human, cheese, and meat) is distinguished by colours of the circles. The numbers on the connecting lines illustrate the number of differing alleles in a pairwise comparison. Clinical Microbiology and Infection 2014 20, 431-436DOI: (10.1111/1469-0691.12638) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 Occurrence of Listeria monocytogenes serovar 1/2b in food samples tested in Austria 2013: cluster strain in comparison with noncluster strains. Outbreak investigation started on 22 January 2013. The producer of the unaged soft cheese, producer A, was first contacted on 26 February, and the producer of the ready-to-eat meat, producer B, on 4 March. Raised awareness and resulting intensification of in-factory sanitation caused the cluster strain to disappear. Clinical Microbiology and Infection 2014 20, 431-436DOI: (10.1111/1469-0691.12638) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions