Volume 68, Issue 1, Pages 4-6 (October 2010)

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Volume 68, Issue 1, Pages 4-6 (October 2010) Snapin Snaps into the Dynein Complex for Late Endosome-Lysosome Trafficking and Autophagy Michisuke Yuzaki Neuron Volume 68, Issue 1, Pages 4-6 (October 2010) DOI: 10.1016/j.neuron.2010.09.036 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Model for Snapin-Regulated Trafficking of Late Endosomes In wild-type neurons (top), snapin links dynein motors to the late endosomes and facilitates their retrograde trafficking along microtubules toward the minus (–) end. The same pathway is used to transport acid-hydrolase-containing late endosomes, which will be fused with immature lysosomes to form mature lysosomes. Mature lysosomes are necessary to form autolysosomes. In snapin-null neurons (bottom), late endosomes cannot be recruited to dynein motors, resulting in accumulation of standstill late endosomes in axons. Reduced trafficking of late endosomes also results in accumulation of immature lysosomes and reduction of autolysosomes. Neuron 2010 68, 4-6DOI: (10.1016/j.neuron.2010.09.036) Copyright © 2010 Elsevier Inc. Terms and Conditions