LKB1 Regulated Pathways in Lung Cancer Invasion and Metastasis

Slides:



Advertisements
Similar presentations
Lung Adenocarcinoma with Ipsilateral Breast Metastasis: A Simple Coincidence? Hsu-Ching Huang, MD, Jen-Fan Hang, MD, Mei-Han Wu, MD, Teh-Ying Chou, MD,
Advertisements

Choroidal Metastases Responsive to Crizotinib Therapy in a Lung Adenocarcinoma Patient with ALK 2p23 Fusion Identified by ALK Immunohistochemistry Yan.
A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma Lu Chen, PhD, Brienne E. Engel, PhD, Eric A. Welsh,
Massive Bronchogenic Cyst Joseph B. Levin, BA, Chi Wan Koo, MD, Jessica S. Donington, MD Journal of Thoracic Oncology Volume 5, Issue 11, Pages
Primary Small Cell Carcinoma of the Esophagus Jima Lv, MD, Jun Liang, MD, Jinwan Wang, MD, Luhua Wang, MD, Jie He, MD, Zefen Xiao, MD, Weibo Yin, MD Journal.
NUT Rearrangement is Uncommon in Human Thymic Epithelial Tumors Iacopo Petrini, MD, Christopher A. French, MD, Arun Rajan, MD, Michael J. Cameron, MSC,
A Hole in the Heart Journal of Thoracic Oncology
Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,
PUBLISH ONLY Journal of Thoracic Oncology
Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.
SC17.02 Lung Cancer in China: Challenges and Perspectives
ALK FISH and IHC: You Cannot Have One without the Other
OPG/RANKL/RANK Pathway as a Therapeutic Target in Cancer
NA  Journal of Thoracic Oncology 
Electronic Updates for JTO Readers
Hedgehog Signaling Pathway and Lung Cancer
IA05.01 Lung Cancer Cases Journal of Thoracic Oncology
A Brief Report of the Status of Central Nervous System Metastasis Enrollment Criteria for Advanced Non–Small Cell Lung Cancer Clinical Trials: A Review.
Prognostic Impact of Malignant Pleural Effusion at Presentation in Patients with Metastatic Non–Small-Cell Lung Cancer  Daniel Morgensztern, MD, Saiama.
The International Association for the Study of Lung Cancer International Staging Project on Lung Cancer  Peter Goldstraw, MB, FRCS, John J. Crowley, PhD 
Frank Detterbeck, MD  Journal of Thoracic Oncology 
The Thymus and the Immune System: Layered Levels of Control
Ziad Thotathil, MD, FRCR, Jeremy Long, FRACP 
Vascular Endothelial Growth Factor (VEGF) Pathway
A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib  Parneet K. Cheema, MD, MBiotech, FRCPC  Journal.
Mediastinal Lymph Node Examination and Survival in Resected Early-Stage Non– Small-Cell Lung Cancer in the Surveillance, Epidemiology, and End Results.
Late Mediastinal Hematoma Followed by Incisional Metastasis After Video-Assisted Mediastinoscopy  Daniel Pop, MD, Ahmad S. Nadeemy, MD, Nicolas Venissac,
Intratumoral Lymphatic Vessel Involvement is an Invasive Indicator of Completely Resected Pathologic Stage I Non-small Cell Lung Cancer  Masahiko Harada,
Jeffrey Bradley, MD, Issam El Naqa, PhD  Journal of Thoracic Oncology 
Effects of Chemotherapy on Survival of Elderly Patients with Small-Cell Lung Cancer: Analysis of the SEER-Medicare Database  Laura C. Caprario, MD, MS,
Association between Congenital Lung Malformations and Lung Tumors in Children and Adults: A Systematic Review  Arianna Casagrande, MD, Federica Pederiva,
Socioeconomic Status Is Associated with Depressive Severity Among Patients with Advanced Non–Small-Cell Lung Cancer: Treatment Setting and Minority Status.
Strategies to Improve Outcomes of Patients with EGFR-Mutant Non–Small Cell Lung Cancer: Review of the Literature  Caicun Zhou, MD, PhD, Luan Di Yao, MD 
A Hole in the Heart Journal of Thoracic Oncology
PUBLISH ONLY Journal of Thoracic Oncology
Imaging Requirements in the Practice of Pulmonary Metastasectomy
Ann G. Schwartz, PhD, Michele L. Cote, PhD, Angela S
Explore the Radiotherapeutic Clinical Target Volume Delineation for Thoracic Esophageal Squamous Cell Carcinoma from the Pattern of Lymphatic Metastases 
Positron Emission Tomography 18F-Fluorodeoxyglucose Uptake and Prognosis in Patients with Surgically Treated, Stage I Non-small Cell Lung Cancer: A Systematic.
Vamsidhar Velcheti, MD  Journal of Thoracic Oncology 
A first start for lung transplantation?
Volume 143, Issue 6, (December 2010)
Iris Metastasis in Small-Cell Lung Carcinoma
Mitotic Inhibitors Journal of Thoracic Oncology
A Translational View of the Molecular Pathogenesis of Lung Cancer
A Primer on Health Economic Evaluations in Thoracic Oncology
Mirror Mirror on the Wall, Who Is the Fairest of Them All
MTP13-01: Indications and limitations of bronchoscopy
Trends in Stage Distribution for Patients with Non-small Cell Lung Cancer: A National Cancer Database Survey  Daniel Morgensztern, MD, Shean Huey Ng,
Multiple Primary Cancers or Multiple Metastases, That Is the Question
Peripheral Direct Adjacent Lobe Invasion Non-small Cell Lung Cancer Has a Similar Survival to That of Parietal Pleural Invasion T3 Disease  Hao-Xian Yang,
Pulmonary Metastasectomy in Breast Cancer
MET 14 Deletion in Sarcomatoid Non-Small-Cell Lung Cancer Detected by Next- Generation Sequencing and Successfully Treated with a MET Inhibitor  Carrie.
T4 or MI? Journal of Thoracic Oncology Volume 6, Issue 3, (March 2011)
Reviewer Acknowledgment
Jie Huang, Juan Peng, Linlang Guo, MD, PhD 
The Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Lung Cancer: Still Following the Right TRAIL?  Emmet E. McGrath, MB, PhD  Journal of Thoracic.
Table of Contents Journal of Thoracic Oncology
Genetic Changes in Squamous Cell Lung Cancer: A Review
Ethnic Differences in the Management of Lung Cancer in New Zealand
European Lung Cancer Conference (ELCC) 2016 Organisation
Trichomegaly of the Eyelashes After Treatment with Erlotinib in Non-small Cell Lung Cancer  Judith Elizabeth Carser, MB, BCh, MRCR, Yvonne Jane Summers,
S-1 Treatment for Chemorefractory Thymic Carcinoma
IASLC 6th Latin American Conference on Lung Cancer
Tumor Lysis Syndrome in Limited-Stage Small-Cell Lung Cancer
A B3 Type-Thymoma in a 7-Year-Old Child with Myasthenia Gravis
A Review of First-Line Treatment for Small-cell Lung Cancer
Mark A. Socinski, MD  Journal of Thoracic Oncology 
Role of the Wnt Signaling Pathway and Lung Cancer
Robert Comis, MD, The Passing of a “Lung Man”
Presentation transcript:

LKB1 Regulated Pathways in Lung Cancer Invasion and Metastasis Adam I. Marcus, PhD, Wei Zhou, PhD  Journal of Thoracic Oncology  Volume 5, Issue 12, Pages 1883-1886 (December 2010) DOI: 10.1097/JTO.0b013e3181fbc28a Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 LKB1-dependent pathways related to motility and metastasis. LKB1-dependent cytoplasmic pathways that regulate epithelial cell polarity, cell polarity during motility, cell detachment/adhesion, and anoikis. For simplicity, the pathways are not shown in full. Journal of Thoracic Oncology 2010 5, 1883-1886DOI: (10.1097/JTO.0b013e3181fbc28a) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions