Patrick M. Boyle et al. JACEP 2018;4:

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Presentation transcript:

Patrick M. Boyle et al. JACEP 2018;4:155-167 Optogenetic Defibrillation of VT in Mice (In Vitro) and Humans (In Silico) (A) Electrocardiogram (ECG) signal recorded from ChR2-expressing mouse heart during ventricular tachycardia (VT) initiation (black bar), perpetuation, and successful optogenetic termination (blue). (B, C) Pseudo-ECG from simulated patient heart with no illumination and red-light illumination (red), resulting in VT termination. Yellow triangles indicate electrical stimuli. (D) Snapshots of voltage distribution at instants indicated by dashed lines in C; right ventricular wall is cut away for visualization. Red triangles indicate light-induced excitations; black arrows indicate propagating VT wavefronts. Patrick M. Boyle et al. JACEP 2018;4:155-167 2018 American College of Cardiology Foundation