Early treatment response affects signal detection in a placebo-controlled depression study  Steven D. Targum, Christopher J. Catania  Personalized Medicine in Psychiatry   Volume 4, Pages 19-24 (December 2017) DOI: 10.1016/j.pmip.2017.10.001 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Early QIDS-SR16 improvement and eventual treatment response*. *Early improvement reflects the change of total QIDS-SR16 score between baseline and week 2. QIDs-SR16 treatment response at 6 weeks is defined as ≥50% improvement from baseline. Personalized Medicine in Psychiatry  2017 4, 19-24DOI: (10.1016/j.pmip.2017.10.001) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Impact of early QIDS-SR16 treatment response on eventual treatment outcome. *post-hoc exclusion of 32 subjects with a conventional treatment response (≥50% QIDS-SR16 improvement from baseline) within 2 weeks following randomization (weeks 0–2). Personalized Medicine in Psychiatry  2017 4, 19-24DOI: (10.1016/j.pmip.2017.10.001) Copyright © 2017 The Authors Terms and Conditions