Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia Srividya Sridhara, Karthik.

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Presentation transcript:

Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia Srividya Sridhara, Karthik Ravi, Thomas C. Smyrk, Hirohito Kita, Gail M. Kephart, Catherine R. Weiler, David A. Katzka Clinical Gastroenterology and Hepatology Volume 10, Issue 7, Pages 735-741 (July 2012) DOI: 10.1016/j.cgh.2012.01.008 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Staining for (A) EDN and (B) MBP in the same area of biopsy in a patient with GERD. (C) Linear MBP staining pattern in a patient with EoE. Clinical Gastroenterology and Hepatology 2012 10, 735-741DOI: (10.1016/j.cgh.2012.01.008) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 EDN staining. (A) EoE patient with grade 3 extracellular staining (white rectangles) and grade 2 intracellular staining (white circles). (B) GERD with grade 3 intracellular and grade 1 extracellular staining. (C) Barrett's esophagus with grade 2 intracellular and extracellular staining. Clinical Gastroenterology and Hepatology 2012 10, 735-741DOI: (10.1016/j.cgh.2012.01.008) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 Staining for (A) EDN and (B) tryptase (brown staining) in the same biopsy location for an EoE patient. Clinical Gastroenterology and Hepatology 2012 10, 735-741DOI: (10.1016/j.cgh.2012.01.008) Copyright © 2012 AGA Institute Terms and Conditions

Figure 4 Peak mast cells/HPF vs peak eosinophils/HPF by group. Group 0, EoE; group 1, GERD; and group 2, Barrett's. Clinical Gastroenterology and Hepatology 2012 10, 735-741DOI: (10.1016/j.cgh.2012.01.008) Copyright © 2012 AGA Institute Terms and Conditions