Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft.

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Presentation transcript:

Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency Richard D. Kenagy, PhD, Mete Civelek, PhD, Shinsuke Kikuchi, MD, Lihua Chen, PhD, Anthony Grieff, BA, Michael Sobel, MD, Aldons J. Lusis, PhD, Alexander W. Clowes, MD Journal of Vascular Surgery Volume 64, Issue 1, Pages 202-209.e6 (July 2016) DOI: 10.1016/j.jvs.2014.12.052 Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 1 Migration of saphenous vein cells in response to platelet-derived growth factor (PDGF)-BB as a function of graft outcome. Each symbol represents the mean fold of migration without PDGF for a cell line, and the bar represents the mean value for all nonstenotic or stenotic cell lines. Journal of Vascular Surgery 2016 64, 202-209.e6DOI: (10.1016/j.jvs.2014.12.052) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 2 A, Cell-mediated collagen gel contraction as function of time (mean ± standard error of the mean; n = 7 cell lines). B, Collagen gel contraction at 24 hours is shown as a function of graft outcome. The symbols represent the mean value for each cell line, and the bar represents the mean value for all nonstenotic or stenotic cell lines. Journal of Vascular Surgery 2016 64, 202-209.e6DOI: (10.1016/j.jvs.2014.12.052) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 3 Effect of knockdown of suprabasin (SBSN) or scavenger receptor class A member 5 (SCARA5) on saphenous vein cell collagen gel contraction (A) and proliferation (B). Data are the mean fold (± standard error of the mean) of the scrambled siRNA control of 5 experiments (gel contraction) and 4-7 experiments (proliferation). ∗P = .005 vs scrambled siRNA. Journal of Vascular Surgery 2016 64, 202-209.e6DOI: (10.1016/j.jvs.2014.12.052) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Supplementary Fig (online only) Summary of the network construction procedure. Journal of Vascular Surgery 2016 64, 202-209.e6DOI: (10.1016/j.jvs.2014.12.052) Copyright © 2016 Society for Vascular Surgery Terms and Conditions