Figure 1 The relationship between health fitness and pathogen load

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Figure 1 The relationship between health fitness and pathogen load Figure 1 | The relationship between health fitness and pathogen load. The slope of the lines represent the health cost associated with controlling a given pathogen burden for different groups of hosts in different situations. a | Both host genotypes have the same resistance capacity but host A has a worse tolerance capacity (steeper slope) so a greater health cost. b | The hosts have equivalent tolerance but host B has higher resistance because the pathogen load is lower. c | The hosts have different resistance and tolerance capacities. d | The hosts have equivalent resistance (same pathogen load) and tolerance capacity (same slope) but differ in fitness even in the absence of infection. The difference in fitness across pathogen load is constant indicating that this difference is the result of traits other than defence against infection. Modified with permission from Macmillan Publishers Limited © Schneider, D. S. & Ayres, J. S. Nat. Rev. Immunol. 8, 889–895 (2008). Modified with permission from Macmillan Publishers Limited © Schneider, D. S. & Ayres, J. S. Nat. Rev. Immunol. 8, 889– 895 (2008). Gómez, H. et al. (2017) Metabolic reprogramming and tolerance during sepsis-induced AKI Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.186