Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study Lorenzo Spaggiari, MD, PhD, Giuseppe Marulli, MD, Pietro.

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Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study Lorenzo Spaggiari, MD, PhD, Giuseppe Marulli, MD, Pietro Bovolato, MD, Marco Alloisio, MD, Vittore Pagan, MD, Alberto Oliaro, MD, Giovanni Battista Ratto, MD, Francesco Facciolo, MD, Rocco Sacco, MD, Daniela Brambilla, MS, Patrick Maisonneuve, Eng, Felice Mucilli, MD, Gabriele Alessandrini, MD, Giacomo Leoncini, MD, Enrico Ruffini, MD, Paolo Fontana, MD, Maurizio Infante, MD, Gian Luca Pariscenti, MD, Monica Casiraghi, MD, Federico Rea, MD, PhD The Annals of Thoracic Surgery Volume 97, Issue 6, Pages 1859-1865 (June 2014) DOI: 10.1016/j.athoracsur.2014.01.050 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Postsurgical survival of 518 of patients who underwent extrapleural pneumonectomy (EPP) in nine Italian referral centers between 2000 and 2010, according to presurgical and postsurgical characteristics: (A) sex; (B) histology (other histologies included 69 biphasic, 7 sarcomatoid, and 5 desmoplastic mesotheliomas); (C) stage; and (D) preoperative and postoperative treatments. Female sex (p = 0.001), epithelial histology (p = 0.0001), early stage (stage 0 and stage 1 [p = 0.01]), and trimodality treatment (p = 0.001) were significantly associated with improved survival. Information on adjuvant treatment was missing for 89 patients. (CT = chemotherapy; Epith = epithelial histology; RT = radiotherapy; S = surgery.) The Annals of Thoracic Surgery 2014 97, 1859-1865DOI: (10.1016/j.athoracsur.2014.01.050) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Impact of postoperative complications on short-term outcome of 518 patients who underwent extrapleural pneumonectomy (EPP) in nine Italian referral centers between 2000 and 2010. *Hazard ratios (HR) and 95% confidence intervals (CI) were obtained from a multivariable Cox proportional hazards regression model adjusted for age, sex, tumor histology, induction chemotherapy, and referral center. (ARDS = acute respiratory distress syndrome.) The Annals of Thoracic Surgery 2014 97, 1859-1865DOI: (10.1016/j.athoracsur.2014.01.050) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions