Effects of Nitric Oxide After Cardiac Transplantation in the Setting of Recipient Pulmonary Hypertension Edward P Chen, MD, Hartmuth B Bittner, MD, PhD,

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Presentation transcript:

Effects of Nitric Oxide After Cardiac Transplantation in the Setting of Recipient Pulmonary Hypertension Edward P Chen, MD, Hartmuth B Bittner, MD, PhD, R.Duane Davis, MD, Peter Van Trigt, MD The Annals of Thoracic Surgery Volume 63, Issue 6, Pages 1546-1547 (June 1997) DOI: 10.1016/S0003-4975(97)83845-3

Fig. 1 Preparation of the recipient’s mediastinum after explantation of the native heart. In the bicaval technique of cardiac transplantation, the recipient’s entire right atrium is removed, resulting in separate cuffs around both the superior vena cava and inferior vena cava, while excision of the left atrium leaves a single Carrel patch around the right and left pulmonary veins. The Annals of Thoracic Surgery 1997 63, 1546-1547DOI: (10.1016/S0003-4975(97)83845-3)

Fig. 2 Effects of inhaled nitric oxide (NO) on the mean pulmonary artery pressure (PAP) after bicaval cardiac transplantation in the setting of monocrotaline pyrrole-induced recipient pulmonary hypertension. (∗p < 0.05 versus posttransplantation, 0 ppm NO.) The Annals of Thoracic Surgery 1997 63, 1546-1547DOI: (10.1016/S0003-4975(97)83845-3)

Fig. 3 Effects of inhaled nitric oxide (NO) on the pulmonary vascular resistance (PVR) after bicaval cardiac transplantation in the setting of monocrotaline pyrrole-induced recipient pulmonary hypertension. (∗p < 0.05 versus posttransplantation, 0 ppm NO.) The Annals of Thoracic Surgery 1997 63, 1546-1547DOI: (10.1016/S0003-4975(97)83845-3)

Fig. 4 Effects of inhaled nitric oxide (NO) on the pulmonary vascular impedance spectrum after bicaval cardiac transplantation in the setting of monocrotaline pyrrole-induced recipient pulmonary hypertension. (RIN = input resistance; Z0 = characteristic impedance; ∗p < 0.05 versus posttransplantation, 0 ppm NO.) The Annals of Thoracic Surgery 1997 63, 1546-1547DOI: (10.1016/S0003-4975(97)83845-3)

Fig. 5 Effects of inhaled nitric oxide (NO) on the transpulmonary efficiency (EFF) after bicaval cardiac transplantation in the setting of monocrotaline pyrrole-induced recipient pulmonary hypertension. (∗p < 0.01 versus posttransplantation, 0 ppm NO.) The Annals of Thoracic Surgery 1997 63, 1546-1547DOI: (10.1016/S0003-4975(97)83845-3)

Fig. 6 Effects of inhaled nitric oxide (NO) on right ventricular preload recruitable stroke work (RV PRSW) after bicaval cardiac transplantation in the setting of monocrotaline pyrrole-induced recipient pulmonary hypertension. There were no significant changes in the RV PRSW after administration of NO at both 40 ppm and 80 ppm compared with 0 ppm. The Annals of Thoracic Surgery 1997 63, 1546-1547DOI: (10.1016/S0003-4975(97)83845-3)