Can an airway challenge test predict respiratory diseases

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Can an airway challenge test predict respiratory diseases Can an airway challenge test predict respiratory diseases? A population-based international study Alessandro Marcon, PhD, Isa Cerveri, MD, Matthias Wjst, MD, Josep Antó, MD, PhD, Joachim Heinrich, PhD, Christer Janson, MD, Deborah Jarvis, MBBS, MRCP, FFPH, MD, Bénédicte Leynaert, PhD, Nicole Probst-Hensch, Dr phil II, PhD, MPH, Cecilie Svanes, MD, PhD, Kjell Toren, MD, Peter Burney, MD, Roberto de Marco, PhD Journal of Allergy and Clinical Immunology Volume 133, Issue 1, Pages 104-110.e4 (January 2014) DOI: 10.1016/j.jaci.2013.03.040 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Number of subjects who were included in the analyses. MCT, Methacholine challenge test. *Free from asthma at baseline. †Free from COPD at baseline (and never reporting asthma). ‡Free from allergic rhinitis at baseline. Journal of Allergy and Clinical Immunology 2014 133, 104-110.e4DOI: (10.1016/j.jaci.2013.03.040) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Distribution of the baseline slope, with the quintiles indicated in boxes, among the subjects who underwent spirometry and methacholine challenge tests at both surveys (n = 3851). Journal of Allergy and Clinical Immunology 2014 133, 104-110.e4DOI: (10.1016/j.jaci.2013.03.040) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Distribution of the baseline slope in subjects with PD20 values of greater than 1 mg of methacholine (n = 3471 [90%]) and 1 mg of methacholine or less (n = 380 [10%]) among the subjects who underwent spirometry and methacholine challenge tests at both surveys (n = 3851). Boxes represent the median with interquartile range of the slope distribution, and whiskers represent the 1.5 * interquartile range limits. Black “x” symbols represent subjects with the highest degree of airway responsiveness (slope, 6.5-1.2); gray “+” symbols represent subjects with a lower degree of responsiveness (slope, 20-6.6). Journal of Allergy and Clinical Immunology 2014 133, 104-110.e4DOI: (10.1016/j.jaci.2013.03.040) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions