Altered first-trimester screening markers after IVF/ICSI: no relationship with small-for- gestational-age and number of embryos transferred F. Bender,

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Altered first-trimester screening markers after IVF/ICSI: no relationship with small-for- gestational-age and number of embryos transferred F. Bender, J. Hecken, J. Reinsberg, C. Berg, H. van der Ven, U. Gembruch, A. Geipel Reproductive BioMedicine Online Volume 20, Issue 4, Pages 516-522 (April 2010) DOI: 10.1016/j.rbmo.2009.12.025 Copyright © 2009 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Distribution of PAPP-A values in IVF, ICSI and spontaneously conceived pregnancies with small-for-gestational-age infants (SGA) and appropriate-for-gestational-age (AGA) fetal growth. Grey=spontaneous conception; lines=IVF; white=ICSI; dots=outliers. Horizontal bars show medians, boxes show upper and lower quartiles, whiskers show range. Statistical test results based on Mann–Whitney U-test: (a) P<0.005 for SGA versus AGA pregnancies in spontaneous conception; (b) P=0.02 for SGA versus AGA pregnancies in IVF; (c) not statistically significant for SGA versus AGA pregnancies in ICSI; (d) P<0.005 for AGA pregnancies after IVF and ICSI compared with spontaneous conception (−0.05 and −0.06 versus 0.03). Reproductive BioMedicine Online 2010 20, 516-522DOI: (10.1016/j.rbmo.2009.12.025) Copyright © 2009 Reproductive Healthcare Ltd. Terms and Conditions