Quantitative genetic study of amphiregulin and fractalkine circulating levels – potential markers of arthropathies  A. Leonov, S. Trofimov, S. Ermakov, G. Livshits  Osteoarthritis and Cartilage  Volume 19, Issue 6, Pages 737-742 (June 2011) DOI: 10.1016/j.joca.2011.02.013 Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Bar plot of mean circulating levels of AREG and FRACT among the individuals with diagnosed arthropathies and in the control group. Mean values and their respective standard errors are presented. The data were log-transformed and standardized prior to comparison. N ("Not Affected")=736, N ("OA of Synovial Joints")=57, N ("Disc Degenerative Disease")=130, N ("All Arthropathies")=187. The data on circulating levels of each of the biomarkers, AREG and FRACT, were log-transformed to achieve normality of the distribution, and then were standardized for the sample mean (z-standardization). Osteoarthritis and Cartilage 2011 19, 737-742DOI: (10.1016/j.joca.2011.02.013) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mid-Parent – Offspring correlations for log-transformed and standardized AREG and FRACT plasma levels. AREG (Offspring)=0.0659+0.2397×AREG (Mid-Parent); FRACT(Offspring)=0.0177+0.2953×FRACT (Mid-Parent). The data on circulating levels of each of the biomarkers, including AREG and FRACT, were log-transformed to achieve normality of the distribution, and then were standardized for the sample mean (z-standardization). Osteoarthritis and Cartilage 2011 19, 737-742DOI: (10.1016/j.joca.2011.02.013) Copyright © 2011 Osteoarthritis Research Society International Terms and Conditions