Efren Rael, MD, FAAAAI Journal of Allergy and Clinical Immunology

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Unraveling the complexity of leukotriene and prostaglandin inflammatory signaling Efren Rael, MD, FAAAAI Journal of Allergy and Clinical Immunology Volume 137, Issue 1, Pages 299-300 (January 2016) DOI: 10.1016/j.jaci.2015.09.003 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Synergy: mast cell activation, vascular inflammation through CysLT1R, and EP3. BLT, Leukotriene B4 receptor; FLAP, 5-lipoxygenase activating protein; HPETE, 5-hydroperoxyeicosatetraenoic acid; 5-LO, 5-lipoxygenase; LTC4S, leukotriene C4 synthase; PGDS, prostaglandin D2 synthase; PGES, prostaglandin E synthase; PGF2α, prostaglandin F2α; PGH2 9-11KR, prostaglandin H2 9-11-endoperoxide reductase; PKG, protein kinase G; TXA2, thromboxane A2. Journal of Allergy and Clinical Immunology 2016 137, 299-300DOI: (10.1016/j.jaci.2015.09.003) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions