Figure 2 APCs from laquinimod-treated mice inhibit differentiation of Tfh cells APCs from laquinimod-treated mice inhibit differentiation of Tfh cells.

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Figure 2 APCs from laquinimod-treated mice inhibit differentiation of Tfh cells APCs from laquinimod-treated mice inhibit differentiation of Tfh cells Splenic CD90.2− cells from mice treated in vivo with laquinimod or vehicle were used as APCs in a reciprocal manner to stimulate naive (CD4+CD44−CD62L+) T cells from MOG p35-55 T cell receptor transgenic mice (2D2) treated with laquinimod or vehicle. APCs and T cells were cultured with MOG p35-55 in Tfh-polarizing conditions (IL-6, IL-21, anti-IL-4, -IL-12, -IFN-γ and -TGF-β antibodies) from the start of culture. Flow cytometry analysis for expression of Tfh cell markers was performed after 3 days of culture. APC = antigen-presenting cell; IFN-γ = interferon γ; IL = interleukin; LAQ = laquinimod; MOG = myelin oligodendrocyte glycoprotein; PD-1 = programmed cell death protein 1; Tfh = T follicular helper; TGF-β = transforming growth factor β; Veh = vehicle. Michel Varrin-Doyer et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e272 © 2016 American Academy of Neurology