Spread of a new Chlamydia trachomatis variant from men who have sex with men to the heterosexual population after replacement and recombination in ompA.

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

Molecular surveillance of measles and rubella in the WHO European Region: new challenges in the elimination phase S. Santibanez, J.M. Hübschen, M.C.

R. Dumke, H. von Baum, P.C. Lück, E. Jacobs

L. Boyanova Clinical Microbiology and Infection

The rise of ampicillin-resistant Enterococcus faecium high-risk clones as a frequent intestinal colonizer in oncohaematological neutropenic patients on.

Molecular epidemiology suggests Venezuela as the origin of the dengue outbreak in Madeira, Portugal in 2012–2013 L. Franco, I. Pagan, N. Serre Del Cor,

Migrant health—a cause for concern?

High-level quinolone resistance is associated with the overexpression of smeVWX in Stenotrophomonas maltophilia clinical isolates G. García-León, C.

Detection of Anaplasma phagocytophilum and Ehrlichia sp

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

A.K. Reddy, P. Garg, I. Kaur Clinical Microbiology and Infection

Fast and low-cost decentralized surveillance of transmission of tuberculosis based on strain-specific PCRs tailored from whole genome sequencing data:

Genetic detection of Dobrava/Belgrade virus in a Czech patient with Haemorrhagic fever with renal syndrome A. Papa, H. Zelená, D. Barnetová, L. Petroušová

A comparison of three real-time PCR assays for the confirmation of Neisseria gonorrhoeae following detection of N. gonorrhoeae using Roche COBAS AMPLICOR

R. Cantón Clinical Microbiology and Infection

Genital Chlamydia trachomatis infections

Clinical and epidemiological characterization of a lymphogranuloma venereum outbreak in Madrid, Spain: co-circulation of two variants M. Rodríguez-Domínguez,

Suppurative mediastinitis after open-heart surgery: a comparison between cases caused by Gram-negative rods and by Gram-positive cocci M.J. Rodríguez-Hernández,

Large increase of rotavirus diarrhoea in the hospital setting associated with emergence of G12 genotype in a highly vaccinated population in Nicaragua

W. Li, L. Liu, X. Jiang, X. Guo, M. Garnier, D. Raoult, P. Parola

G. Griesinger, G. Gille, C. Klapp, S. von Otte, K. Diedrich

Chlamydia trachomatis infections in heterosexuals attending sexually transmitted disease clinics in Slovenia D. Kese, M. Maticic, M. Potocnik Clinical.

Genome-based insights into the evolution of enterococci

The importance of enterovirus surveillance in a Post-polio world

M. Micaëlo, A. Goubard, G. La Ruche, E. Denamur, O. Tenaillon, E

Tracking human migration patterns through the oral bacterial flora

L. Moles, M. Gómez, E. Jiménez, L. Fernández, G. Bustos, F. Chaves, R

Successful control of a large outbreak of HIV infection associated with injection of cathinone derivatives in Tel Aviv, Israel E. Katchman, R. Ben-Ami,

Vector control: a cornerstone in the malaria elimination campaign

Differences in the robustness of clusters involving the Mycobacterium tuberculosis strains most frequently isolated from immigrant cases in Madrid N.

Clostridium innocuum is a significant vancomycin-resistant pathogen for extraintestinal clostridial infection J.-H. Chia, Y. Feng, L.-H. Su, T.-L. Wu,

A comparison of three real-time PCR assays for the confirmation of Neisseria gonorrhoeae following detection of N. gonorrhoeae using Roche COBAS AMPLICOR

Unexpectedly high prevalence of Treponema pallidum infection in the oral cavity of human immunodeficiency virus-infected patients with early syphilis.

F. Aujoulat, H. Marchandin, I. Zorgniotti, A. Masnou, E. Jumas-Bilak

P. Seng, J.M. Rolain, D. Raoult, P. Brouqui

A novel method for the rapid and prospective identification of Beijing Mycobacterium tuberculosis strains by high-resolution melting analysis M. Alonso,

Detection of causative agents of tick-borne rickettsioses in Western Siberia, Russia: identification of Rickettsia raoultii and Rickettsia sibirica DNA.

The occurrence of Legionella species other than Legionella pneumophila in clinical and environmental samples in Denmark identified by mip gene sequencing.

F. Magurano Clinical Microbiology and Infection

Human infection with H9N2 avian influenza in northern China

The role of tigecycline in the management of Clostridium difficile infection: a retrospective cohort study E. Manea, J. Sojo-Dorado, R.E. Jipa, S.N.

Evidence of horizontal gene transfer between amoeba and bacteria

M.D. Blanco Fernández, C. Torres Clinical Microbiology and Infection

S. Moore, N. Thomson, A. Mutreja, R. Piarroux

Mathematical modeling of Clostridium difficile infection

Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma

Whole genome-based phylogenetic analysis of Rickettsiae

Hepatitis B virus in Buenos Aires, Argentina: genotypes, virological characteristics and clinical outcomes S.C. Pezzano, C. Torres, H.A. Fainboim, M.B.

The mosaic genome structure and phylogeny of Shiga toxin-producing Escherichia coli O104:H4 is driven by short-term adaptation K. Zhou, M. Ferdous, R.F.

The significance of rhinovirus detection in hospitalized children: clinical, epidemiological and virological features J.C. Rahamat-Langendoen, A. Riezebos-Brilman,

V. Andriantsoanirina, F. Ariey, A. Izri, C. Bernigaud, F. Fang, R

Emergence of Crimean–Congo haemorrhagic fever in Greece

Tuberculosis transmission patterns among Spanish-born and foreign-born populations in the city of Barcelona S. Borrell, G. Tudó, E. Rey, J. González-Martín

Accurate hepatitis C virus genotyping and selection of optimal therapy: lessons from a St Petersburg strain infection E. Knops, E. Heger Clinical Microbiology.

Comparison of different methods for identification of species of the genus Raoultella: report of 11 cases of Raoultella causing bacteraemia and literature.

D. -L. Zhang, Y. Jin, D. -D. Li, W. -X. Cheng, Z. -Q. Xu, J. -M. Yu, M

A.P. Underwood, J. Green Clinical Microbiology and Infection

First isolation of Conidiobolus sp

M.T. Pérez-Rodríguez, A. Sousa, P. Martínez-Cueto, A. Ocampo

Detection of a new subgenotype of hepatitis B virus genotype A in Cameroon but not in neighbouring Nigeria J.M. Hübschen, P.O. Mbah, J.C. Forbi, J.A.

Virology: a scientific discipline facing new challenges

M. Biçmen, Z. Gülay, S.V. Ramaswamy, D.M. Musher, D. Gür

T. A. Nguyen, L. P. Hoang, L. D. Pham, K. T. Hoang, S. Okitsu, M

The L2b real-time PCR targeting the pmpH gene of Chlamydia trachomatis used for the diagnosis of lymphogranuloma venereum is not specific to L2b strains

Bloodstream infections due to Peptoniphilus spp.: report of 15 cases

J.L. Balcázar Clinical Microbiology and Infection

Overall trends in CD4 counts and plasma viremia in an urban clinic since the introduction of highly active antiretroviral therapies J.C. Martín, V Soriano,

CMI readers' survey Clinical Microbiology and Infection

The future of diagnostic bacteriology

Presentation transcript:

Spread of a new Chlamydia trachomatis variant from men who have sex with men to the heterosexual population after replacement and recombination in ompA and pmpH genes M. Rodríguez-Domínguez, J.M. González-Alba, T. Puerta, L. Martínez-García, B. Menéndez, R. Cantón, J. del Romero, J.C. Galán Clinical Microbiology and Infection Volume 23, Issue 10, Pages 761-766 (October 2017) DOI: 10.1016/j.cmi.2017.03.009 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 (a) Temporal evolution of Chlamydia trachomatis strains carrying the recombinant pmpH gene during the periods of time described. The pmpH-recombinant variant was detected by PCR on direct sample. (b) Annual detection of pmpH-recombinant C. trachomatis strains depending on from where the samples were taken. Solid colours represent the recombinant variant and striped colours correspond to the non-recombinant variant. Clinical Microbiology and Infection 2017 23, 761-766DOI: (10.1016/j.cmi.2017.03.009) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Distribution of symptomatic and asymptomatic Chlamydia trachomatis infections carrying pmpH-recombinant gene, depending on the type of the sample. Co-STD, co-infections caused by C. trachomatis and other sexually transmitted diseases simultaneously, in this series all cases were Neisseria gonorrhoeae. Clinical Microbiology and Infection 2017 23, 761-766DOI: (10.1016/j.cmi.2017.03.009) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 (a) Maximum likelihood (ML) phylogeny of pmpH gene from Chlamydia trachomatis. The different pathotypes are easily differentiated (bootstrap ≥99). This phylogenetic tree was performed with all pmpH sequences available in GenBank. (b) ML phylogeny of five concatenated genes (pmpH, rs2, lysS, incE-F and ompA). Those sequences with detected recombinant events in this gene are shown in bold. The red bold sequences correspond to a recombinant closely related to pmpH found in Madrid, whereas light blue represents the recombinant variants detected in Seattle. Clinical Microbiology and Infection 2017 23, 761-766DOI: (10.1016/j.cmi.2017.03.009) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 4 Bayesian analysis of concatenated genes. Using strains belonging to recombinant pmpH variants from Madrid, non-recombinant genes were concatenated and phylogenies were obtained using a Bayesian Markov chain Monte Carlo method implemented in BEAST v1.5.74 program. Clinical Microbiology and Infection 2017 23, 761-766DOI: (10.1016/j.cmi.2017.03.009) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions