Teratogenic effects of retinoic acid on neurulation in mice embryos

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Presentation transcript:

Teratogenic effects of retinoic acid on neurulation in mice embryos M. Nobakht, A. Zirak, M. Mehdizadeh, P. Tabatabaeei Pathophysiology Volume 13, Issue 1, Pages 57-61 (February 2006) DOI: 10.1016/j.pathophys.2005.07.003 Copyright © 2005 Terms and Conditions

Fig. 1 Appearance of embryos of mice dams, which have received RA (from left to right): 40 and 60mg/kg on the eighth day of gestation and control. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 2 The embryo from a dam having received 40mg/kg RA. The arrow indicates head cleft. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 3 The embryo from a dam having received 60mg/kg RA. Arrow indicates the prolonged cranium and the small arrow indicates facial cleft. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 4 Transverse paraffin section of closure neural tube of 10-day old embryo of a dam exposed to DMSO. Lumen (L), bar line=300μm. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 5 Transverse epon section of neural tube of 10-day old embryo from a dam exposed to DMSO. Nucleoli (light arrow), mitosis (dark arrow), bar line=50μm. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 6 Transverse paraffin section of non-closure (arrow) neural tube of 10-day old embryo of a dam exposed to 40mg/kg RA on the eighth day of gestation: ganglionic spinal (Gs), bar line=300μm. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 7 Transverse paraffin section of neural tube of 10-day old embryo of a dam exposed to 40mg/kg RA on the eighth day of gestation. The light arrow indicates disorganization of neuroepitbelium and the dark arrow indicates closure neural tube, bar line=100μm. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 8 Transverse epon section of neural tube of 10-day old embryo of a dam exposed to 40mg/kg RA on the eighth day of gestation. The density of chromatin and the number of nucleoli were decreased: venteral zone (Vz); mantle zone (Maz); marginal zone (Mrz), bar line=100μm. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 9 Transverse paraffin section of non-closure (arrow) neural tube of 10-day old embryo from a dam exposed to 60mg/kg RA on the eighth days of gestation: lumen (L); ganglionic spinal (Gs), bar line=300μm. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 10 Transverse epon section of the neural tube of 10-day old embryo exposed to 60mg/kg RA on the eighth day of gestation heterochromatin (light arrow), mitosis (dark arrow), bar line=50μm. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 11 The comparison of longitudinal, medial and lateral measures (in μm) of the neural tube, embryos of control and RA exposed (on the eighth day of gestation) dams on the 10th day of gestation. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions

Fig. 12 The comparison of thickness of ventricular, mantle and marginal layers (in μm) of the neural tube embryos of control and RA exposed (on the eighth day) dams on the 10th day of gestation. Pathophysiology 2006 13, 57-61DOI: (10.1016/j.pathophys.2005.07.003) Copyright © 2005 Terms and Conditions