Michele Curcio, Frank Bradke Neuron

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Microtubule Organization in the Axon: TRIM46 Determines the Orientation Michele Curcio, Frank Bradke Neuron Volume 88, Issue 6, Pages 1072-1074 (December 2015) DOI: 10.1016/j.neuron.2015.12.006 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 A Model for Microtubule Organization at the Proximal Axon (A) Schematic of a developing neuron and composition of the proximal domain of its future axon. (B) Schematic of a polarized neuron and composition of its AIS. van Beuningen et al. (2015) found that the microtubule-associated protein TRIM46 localizes to the proximal domain of the axon, where it forms parallel microtubule arrays required for the initial axon specification and for the maintenance of neuronal polarity. Indeed, depletion of TRIM46 alters the orientation of microtubules, the distribution of Ankyrin G in developing neurons and the distribution of Dephospho-Tau (antibody clone PC1C6) in polarized neurons. Neuron 2015 88, 1072-1074DOI: (10.1016/j.neuron.2015.12.006) Copyright © 2015 Elsevier Inc. Terms and Conditions