Recombinant Human Granulocyte Colony-Stimulating Factor Significantly Decreases the Expression of CXCR3 and CCR6 on T Cells and Preferentially Induces.

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Recombinant Human Granulocyte Colony-Stimulating Factor Significantly Decreases the Expression of CXCR3 and CCR6 on T Cells and Preferentially Induces T helper Cells to a T helper 17 Phenotype in Peripheral Blood Harvests Li-Xia Sun, Han-Yun Ren, Yong-Jin Shi, Li-Hong Wang, Zhi-Xiang Qiu Biology of Blood and Marrow Transplantation Volume 15, Issue 7, Pages 835-843 (July 2009) DOI: 10.1016/j.bbmt.2009.03.016 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 CXCR3 expression on T cells in rhG-CSF-mobilized PBSC grafts (light symbols) and SS-PB (dark symbols). Mean values are represented by horizontal lines in each series. (A) Representative example of CXCR3 expression on CD3+, CD4+, and CD8+ T cells in SS-PB and PBSC grafts. (B) Percentages of CXCR3 expression on CD3+, CD4+, and CD8+ T cells before and after in vivo rhG-CSF application. Biology of Blood and Marrow Transplantation 2009 15, 835-843DOI: (10.1016/j.bbmt.2009.03.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 CCR6 expression on T cells in rhG-CSF-mobilized PBSC grafts (light symbols) and SS-PB (dark symbols). Mean values are represented by horizontal lines in each series. (A) Representative example of CCR6 expression on CD3+, CD4+, and CD8+ T cells in SS-PB and PBSC grafts. (B) Percentages of CCR6 expression on CD3+, CD4+, and CD8+ T cells before and after in vivo rhG-CSF application. Biology of Blood and Marrow Transplantation 2009 15, 835-843DOI: (10.1016/j.bbmt.2009.03.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Effect of rhG-CSF on IFN-γ, IL-4, and IL-17 production by CD4+ Th cells. Bars represent percentages (mean ± SD) in IFN-γ-, IL-4-, and IL-17–expressing CD4+ Th cells before (light bars) and after (black bars) rhG-CSF mobilization. P values were determined using t-tests for paired samples. ∗P < .01, ∗∗P < .05. (A) Mean percentages of IFN-γ-, IL-4-, and IL-17-producing CD4+ Th cells. (B) Representative example of IL-17-producing CD4+ T cells before and after rhG-CSF application. Biology of Blood and Marrow Transplantation 2009 15, 835-843DOI: (10.1016/j.bbmt.2009.03.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Ratios of IFN-γ-, IL-4-, and IL-17-producing CD4+ Th cells in SS-PB (light bars) and rhG-CSF-mobilized PBSC grafts (dark bars). ∗P < .01. Biology of Blood and Marrow Transplantation 2009 15, 835-843DOI: (10.1016/j.bbmt.2009.03.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Relative expression levels of TCRBV family members in SS-PB (light bars) and rhG-CSF-mobilized PBSC graft (dark bars). P values were determined using t-tests for paired samples. All P > .05. Biology of Blood and Marrow Transplantation 2009 15, 835-843DOI: (10.1016/j.bbmt.2009.03.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions