Flavonoid DAPI Mitotracker

Slides:



Advertisements
Similar presentations
Supplementary figure 1 Supplementary Fig. S1: Age dependent changes in db/db and db/dm mice. Representative images of PAS-stained kidney sections of db/db.
Advertisements

Supplementary Figure S1. Hematoxylin and eosin (H&E) staining (left panel) and ASP+ fluorescence labeling (right panel) of adjacent sections containing.
Supplementary Figure 2: PBX1 induces morphological and cytoskeletal changes consistent with differentiation in NB. A) Morphology of SHSY5Y cells. Cells.
Supplementary Information The latent origin of replication of Epstein-Barr virus directs viral genomes to active regions of the nucleus Manuel J. Deutsch,
C B *** Cal51 p21 BAX p53 actin PUMA Nutlin3a ABT wt A *** Le Pen et al., figure S mock ABT-737 Nutlin3a ABT-737.
Condition MiaPaCa-2 Control Gem (100nm) AZD1775 (200nM) Gem + AZD1775 Panc-1 Control Gem (50nm) AZD1775 (200nM) Gem + AZD1775 Capan-1 Control Gem (50nm)
Invest. Ophthalmol. Vis. Sci ;49(10): doi: /iovs Figure Legend:
From: CXCL10 Is Required to Maintain T-Cell Populations and to Control Parasite Replication during Chronic Ocular Toxoplasmosis Invest. Ophthalmol. Vis.
Figure 4. Effects of hydrogenized water on SIRT1 expression in human umbilical vein endothelial cells. Human umbilical vein endothelial cells were incubated.
B A P-AXL P-AXL AXL AXL P-MET P-MET MET MET P-Akt-473 P-Akt-473 AKT
Active mitochondria surround the secretory granule area of pancreatic exocrine (acinar) cells and constitute a barrier to Ca2+ diffusion Confocal transmitted.
A B C D Figure S3: DiO6(3) staining of mitochondrial networks in primary prostate tumor organ cultures. (A) Epithelial.
MP30-17 INCREASED TISSUE FACTOR EXPRESSION IS AN INDEPENDENT PREDICTOR OF MORTALITY IN CLEAR CELL CARCINOMA OF THE KIDNEY  DANIEL D OLIVEIRA SILVA, JORGE.
From: GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy Trans. Vis. Sci. Tech ;5(3):1.
From: GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy Trans. Vis. Sci. Tech ;5(3):1.
Figure S1 a b c d DAPI Lgr β-catenin Merge
Fig. 13. Simulation snapshots of 200 sodium hexyl sulfate surfactants with one added polyethylene oxide chain 120 monomers long in water. The red polymer.
Suppl. Figure 3 A H1975 Atg7 shRNA 3 MOI Atg7 shRNA 6 MOI
Supplementary figure 1 D
Supplementary Figure 2 Secondary transplanted brain tumors from PASC1 express human GH. Immuno-fluorescence staining of brain sections from mice implanted.
TUG‐891 increases oxygen consumption by brown adipocytes, mediated by direct UCP1 activation and mitochondrial fragmentation TUG‐891 increases oxygen consumption.
Volume 66, Pages S5-S12 (October 2004)
Peixoto et al, Supplementary Figure 4.1 A(top)
A B C D E CD20 CagA DAPI Merge Supplementary Figure 1.
Supplementary Figure 1 Negative control IC50 110 mM (acetate)
Radiation resistance and stem-like cells in brain tumors
Ang II induces translocation of α-ENaC toward the apical membrane.
Supplementary Figure1. Systemic administration of LPS does not lead to a general induction of EGFP+ expression in CD11b+ microglia in different regions.
Volume 18, Issue 2, Pages (August 2013)
Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery  Martina Tuttolomondo, Cinzia Casella, Pernille Lund Hansen, Ester Polo,
Alveolar lymphangiogenesis is a feature of idiopathic pulmonary fibrosis (IPF). a) Tissue sections reacted with anti-D2-40 (brown) and anti-CD34 (red)
Volume 20, Issue 5, Pages (August 2017)
GFP positive cells detected under confocal microscope
(red) & endothelium (green) PMCA4 (green) & DAPI (blue)
Volume 69, Issue 6, Pages (March 2006)
Alexandra Gampel, Peter J. Parker, Harry Mellor  Current Biology 
Supplementary Figure 1. Structure of amlexanox
A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced cells. A role for galectin-3 in promoting lung colonization in ST6GalNAc2-silenced.
Improved design and localization of mtZFNs Schematic structure of previous mtZFN architecture. Improved design and localization of mtZFNs Schematic structure.
Volume 16, Issue 12, Pages (December 2009)
Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids  Lena Pernas, Camilla Bean, John C.
Volume 9, Issue 1, Pages (October 2014)
Sister-chromatid cohesion via MEI-S332 and kinetochore assembly are separable functions of the Drosophila centromere  Jacqueline M. Lopez, Gary H. Karpen,
Volume 14, Issue 8, Pages (August 2007)
Leto et al., Supplementary Figure S3
Yuri Oleynikov, Robert H. Singer  Current Biology 
Volume 19, Issue 13, Pages (June 2017)
TUG‐891 increases oxygen consumption by brown adipocytes, mediated by direct UCP1 activation and mitochondrial fragmentation TUG‐891 increases oxygen consumption.
A B C D Supplementary Figure S1 UMSCC1 Plateau: 24 hr Pre-Treatment
Vimentin reorganisation requires actin and microtubules.
Inhibition of ROCK activity rescues formation of polarized cysts in the absence of DDR1 signaling. Inhibition of ROCK activity rescues formation of polarized.
CpG-A and CpG-B are distributed in different compartments in PDCs
Indirect fluorescence assay of N. gruberi cells.
Aggresome formation of STAT5A_ΔE18.
Effect of M-cadherin RNAi and GSK-3β inhibition on myogenic differentiation of C2C12 myoblasts. Effect of M-cadherin RNAi and GSK-3β inhibition on myogenic.
Stimulation of mitochondrial embryo metabolism by dichloroacetic acid in an aged mouse model improves embryo development and viability  Nicole O. McPherson,
Colocalization of CD151 with the laminin receptor α7β1 in smooth and skeletal muscle. Colocalization of CD151 with the laminin receptor α7β1 in smooth.
Altered intracellular distributions of acetylated α-tubulin, mitochondria and peroxisomes. Altered intracellular distributions of acetylated α-tubulin,
ChREBPα increases β-cell mitochondrial activity and ATP production in human islets. ChREBPα increases β-cell mitochondrial activity and ATP production.
LPL knockdown by RNAi in RC13 human rhabdomyosarcoma cell line.
Photomicrographs were taken at x400 final magnification.
Volume 14, Issue 4, Pages (February 2016)
Selective delivery of pIC/PPHAffibody decreases the survival of HER2-overexpressing cells. Selective delivery of pIC/PPHAffibody decreases the survival.
KPT-9274 shows specificity for attenuation of PAK4 targets preferentially in RCC cells. KPT-9274 shows specificity for attenuation of PAK4 targets preferentially.
Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs on tumor cells. Binding and antiproliferative effects of ANG4043 and anti-HER2 mAbs.
Volume 15, Issue 4, Pages (February 2005)
Irreplaceability of Neuronal Ensembles after Memory Allocation
Snail-induced multinucleation follows midbody persistence.
Volume 18, Issue 6, Pages (June 2003)
Fig. 5 Distributions of cell nuclear area values and internuclear distances in the breast tumor specimens (Figs. 3 and 4), where bin interval = 8 and n.
Presentation transcript:

3.5µM AO1530 (1 hr, RCC-30, 63x mag) 10µM AO-1486 (1 hr, RCC-30, 63x mag) Flavonoid DAPI Mitotracker 5µM AO-155 (1 hr, RCC-30, 63x mag) 3.5µM OncamexTM (1 hr, RCC-30, 63x mag) Supplementary Figure 2 Intracellular localisation of different novel flavonoids. Confocal images of RCC-30 renal cancer cells 1h after treatment with different novel-flavonoids. Results show the most efficient delivery to the mitochondrial compartment in cells treated with OncamexTM, as visible by the strongest overlap of green and red signals.