Hepatocellular Carcinoma Is the Most Common Indication for Liver Transplantation and Placement on the Waitlist in the United States  Ju Dong Yang, Joseph J. Larson, Kymberly D. Watt, Alina M. Allen, Russell H. Wiesner, Gregory J. Gores, Lewis R. Roberts, Julie A. Heimbach, Michael D. Leise  Clinical Gastroenterology and Hepatology  Volume 15, Issue 5, Pages 767-775.e3 (May 2017) DOI: 10.1016/j.cgh.2016.11.034 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Number of new liver transplant waitlist registrants and recipients in the United States, from 2004 to 2015. (A) Number of new registrants with HCC as a separate indication. (B) Number of new recipients with HCC as a separate indication. (C) Number of new registrants classified by underlying liver disease diagnosis. (D) Number of new recipients classified by underlying liver disease diagnosis. (B and D) The number of LT recipients does not reflect all LT recipients in each index year because only recipients who were listed after 2004 were included (LT recipients who were registered before 2004 were not included in the current figure). Clinical Gastroenterology and Hepatology 2017 15, 767-775.e3DOI: (10.1016/j.cgh.2016.11.034) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 (A) Number of HCC registrants and (B) the ratio of HCC vs non-HCC among new liver transplant waitlist registrants with different underlying etiologies of liver disease. (A) The Y-axis is split. The interval between tick marks is 50 in the lower Y-axis and 200 in the upper Y-axis. (A) Number of HCC registrants with underlying etiology of HCV, HBV, alcohol, or NASH. (B) The ratio of registrants with HCC vs non-HCC classified by underlying etiology of liver disease. Clinical Gastroenterology and Hepatology 2017 15, 767-775.e3DOI: (10.1016/j.cgh.2016.11.034) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 Trends in the probability of liver transplant, drop-out owing resulting from deterioration, and delisting owing to clinical improvement among new liver transplant waitlist registrants in the United States, from 2004 to 2014. *P < .05. Drop, drop-out of list as a result of death or clinical deterioration; Improve, delisting owing to clinical improvement. The X-axis indicates months after listing. The Y-axis indicates probability of LT, drop-out resulting from death or deterioration, and delisting owing to clinical improvement. (A) HCC with HCV. (B) HCC without HCV. (C) HCV. (D) HBV. (E) Alcohol. (F) NASH. Clinical Gastroenterology and Hepatology 2017 15, 767-775.e3DOI: (10.1016/j.cgh.2016.11.034) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 Trends in post-transplant graft failure among liver transplant recipients, from 2004 to 2014. The X-axis indicates months after liver transplant and the Y-axis indicates the probability of graft failure. (A) HCC with HCV. (B) HCC without HCV. (C) HCV. (D) HBV. (E) Alcohol. (F) NASH. Era 1, transplant between 2004 and 2010; Era 2, transplant between 2011 and 2014. Clinical Gastroenterology and Hepatology 2017 15, 767-775.e3DOI: (10.1016/j.cgh.2016.11.034) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 Trends in the number of graft failures among liver transplant recipients in the United States: 2004 to 2015. Clinical Gastroenterology and Hepatology 2017 15, 767-775.e3DOI: (10.1016/j.cgh.2016.11.034) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 2 Trends in post-transplant overall or graft survival among liver transplant recipients in the United States: 2004 to 2014. The X-axis indicates months after liver transplant, the Y-axis indicates the probability of graft failure or overall survival. Clinical Gastroenterology and Hepatology 2017 15, 767-775.e3DOI: (10.1016/j.cgh.2016.11.034) Copyright © 2017 AGA Institute Terms and Conditions