Volume 385, Issue 9984, Pages (June 2015)

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Volume 385, Issue 9984, Pages 2272-2279 (June 2015) Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double- blind, placebo-controlled, phase 1 trial Feng-Cai Zhu, MSc, Li-Hua Hou, PhD, Jing-Xin Li, MSc, Shi-Po Wu, PhD, Prof Pei Liu, PhD, Gui-Rong Zhang, PhD, Yue-Mei Hu, BSc, Fan-Yue Meng, MSc, Jun-Jie Xu, PhD, Rong Tang, MSc, Jin-Long Zhang, PhD, Wen-Juan Wang, MSc, Lei Duan, MSc, Kai Chu, MSc, Qi Liang, MSc, Jia-Lei Hu, MSc, Li Luo, MSc, Tao Zhu, PhD, Jun-Zhi Wang, PhD, Dr Wei Chen, PhD The Lancet Volume 385, Issue 9984, Pages 2272-2279 (June 2015) DOI: 10.1016/S0140-6736(15)60553-0 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet 2015 385, 2272-2279DOI: (10.1016/S0140-6736(15)60553-0) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 2 Glycoprotein-specific T-cell response in all participants (A) and in those with pre-existing adenovirus type-5 neutralising antibody titres ≤1:200 (B) or >1:200 (C) IFN=interferon. PBMC=peripheral blood mononuclear cells. The Lancet 2015 385, 2272-2279DOI: (10.1016/S0140-6736(15)60553-0) Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 3 CD4 and CD8 T-cell response CD4 T-cell response in all participants (A) and those with pre-existing adenovirus type-5 neutralising antibody titres ≤1:200 (B) or >1:200 (C), and CD8 T-cell response in all participants (D) and those with pre-existing adenovirus type-5 antibody titres ≤1:200 (E) or >1:200 (F). The Lancet 2015 385, 2272-2279DOI: (10.1016/S0140-6736(15)60553-0) Copyright © 2015 Elsevier Ltd Terms and Conditions