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A presentation to: Meeting name Date Laser-assisted subepithelial keratectomy (LASEK) versus photorefractive keratectomy (PRK) for correction of myopia Si-Yuan Li, Siyan Zhan, Si-Yuan Li, Ziao-Xia Peng, Jing Hu, Hua Andrew Law, Ning-Li Wang Issue 2, 2016 A presentation to: Meeting name Date

Table of Contents 01 Background 02 Types of studies 03 Key results 04 Tables (Risk of Bias/Forest Plots) 05 Conclusions 06 Acknowledgements

01: Background Myopia (near-sightedness) can be treated with spectacles or refractive procedures LASEK – laser epithelial keratomileusis PRK – photorefractive keratectomy Objective: “To compare LASEK versus PRK for correction of myopia by evaluating their efficacy and safety”

02: Types of studies Participants 11 randomized controlled trials, 428 participants Interventions LASEK vs. PRK

03: Key results “The proportion of eyes with uncorrected visual acuity of 20/20 or better at 12-month follow-up was comparable in LASEK and PRK groups” RR 0.98, 95% CI 0.92 to 1.05 “At 12 months post treatment, data from two trials suggest no difference or a possibly small effect in favor of PRK over LASEK for the proportion of eyes achieving ± 0.50 D of target refraction.” RR 0.93, 95% CI 00.84 to 1.03

04: Tables

05: Conclusions “Uncertainty surrounds differences in efficacy, accuracy, safety, and adverse effects between LASEK and PRK for eyes with low to moderate myopia. Future trials comparing LASEK versus PRK should follow reporting standards and follow correct analysis.”

06: Acknowledgements Cochrane Eyes and Vision US Satellite, funded by the National Eye Institute, National Institutes of Health Cochrane Eyes and Vision Editorial Base, funded by the UK National Health Service Research and Development Programme Si-Yuan Li, Siyan Zhan, Si-Yuan Li, Ziao-Xia Peng, Jing Hu, Hua Andrew Law, Ning-Li Wang Review citation Laser-assisted subepithelial keratectomy (LASEK) versus photorefractive keratectomy (PRK) for correction of myopia. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD009799. DOI: 10.1002/14651858.CD009799.pub2