Caspase-8, Death-Receptor Signaling, and Hepatocarcinogenesis: The Fas and the Furious  Edwina S. Baskin–Bey, Gregory J. Gores  Gastroenterology  Volume 129, Issue 5, Pages 1790-1792 (November 2005) DOI: 10.1053/j.gastro.2005.09.037 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Speculation of the role of caspase-8 silencing in hepatocarcinogenesis. Death-receptor-mediated caspase-8 activation results in apoptosis and cell death. If the caspase-8 promoter is methylated inhibiting SP1 binding and transactivation then cellular fates are switched to that of tumorigenesis, potentially secondary to potentiating the Fas/NF-κB pathway (dashed line). If histone deacetylases (HDAC) or methylase inhibitors are used in this model then the fate of tumor cells can be reversed back to that of cell death. Gastroenterology 2005 129, 1790-1792DOI: (10.1053/j.gastro.2005.09.037) Copyright © 2005 American Gastroenterological Association Terms and Conditions