Kinetochore function: The complications of becoming attached

Slides:



Advertisements
Similar presentations
PROPHASE METAPHASE ANAPHASE TELOPHASE.  Chromosomes condense and nucleoli disappear  Each duplicated chromosome becomes visible as distinct sister chromatids.
Advertisements

M/A: Spindle assembly checkpoints Empirical observations: arrest of mitotic progress in presence of spindle poisons (e.g., colcemid) Delay of mitotic progress.
Molecular Biology of the Cell Fifth Edition Molecular Biology of the Cell Fifth Edition The Cell Cycle.
Primary Research Paper: Cell & Molecular Biology
Mechanisms and Molecules of the Mitotic Spindle
Stephen W Scherer, Joseph Cheung  Current Biology 
Volume 12, Issue 1, Pages (July 2015)
Volume 8, Issue 9, Pages R177-R185 (September 2000)
Mitosis: New Roles for Myosin-X and Actin at the Spindle
Tumor progression: Defining the soil round the tumor seed
DNA repair: Polymerases for passing lesions
Chromatin replication: Finding the right connection
Oncogenic B-Raf mutations
Generalizable Learning: Practice Makes Perfect — But at What?
Sensory-Motor Integration: More Variability Reduces Individuality
Microbiology: Mixing Wine, Chocolate, and Coffee
Kinetochores: NDC80 Toes the Line
Mps1 Checks Up on Chromosome Attachment
Cell Division: Experiments and Modelling Unite to Resolve the Middle
Microtubule Flux: What Is It Good for?
Intermediate Filaments: Vimentin Moves in
Spindle pole bodies Current Biology
Mohan K. Balasubramanian, Erfei Bi, Michael Glotzer  Current Biology 
How Kinetochore Architecture Shapes the Mechanisms of Its Function
Volume 25, Issue 24, Pages R1156-R1158 (December 2015)
Hydra  Kristine M. Glauber, Catherine E. Dana, Robert E. Steele 
Verena N. Lorenz, Michael P. Schön, Cornelia S. Seitz 
Spindle Positioning: Actin Mediates Pushing and Pulling
And the Dead Shall Rise: Actin and Myosin Return to the Spindle
Root patterning: SHORT ROOT on the move
Germ Plasm: Protein Degradation in the Soma
Volume 22, Issue 16, Pages R620-R622 (August 2012)
Volume 23, Issue 7, Pages R265-R266 (April 2013)
Volume 25, Issue 19, Pages R815-R817 (October 2015)
Kinetochore Orientation in Mitosis and Meiosis
Morphogenesis: A Mob Rules from the Rear
Samuel F. Bakhoum, Giulio Genovese, Duane A. Compton  Current Biology 
Structure prediction: The state of the art
The centrosome Current Biology
Order and Disorder in the Nucleus
Mitosis: Too Much of a Good Thing (Can Be Bad)
Kinetochores and Microtubules Wed without a Ring
DNA repair: Rad52 – the means to an end
Cell cycle: Driving the centrosome cycle
Telomeres: The Molecular Events Driving End-To-End Fusions
PLK1 Inhibitors: Setting the Mitotic Death Trap
The spindle assembly checkpoint
Samuel F. Bakhoum, Giulio Genovese, Duane A. Compton  Current Biology 
Chromosome Segregation: Correcting Improperly Attached Chromosomes
Tight junctions: Closing in on the seal
Volume 7, Issue 6, Pages R147-R151 (June 2000)
Osteoarthritis year 2012 in review: biology
Orchestrating Twosome and Foursome Chromosome Parties
Claire E Walczak, Timothy J Mitchison  Cell 
Radhika Subramanian, Tarun M. Kapoor  Developmental Cell 
Cell Cycle: New Functions for Cdc14 Family Phosphatases
Volume 18, Issue 15, Pages R641-R645 (August 2008)
Captivating Capture: How Microtubules Attach to Kinetochores
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death  Beth A.A. Weaver, Don W. Cleveland 
Chromosome Segregation: Not to Put Too Fine a Point (Centromere) On It
NAP5: the tip of the iceberg, or all we need to know?
Tight junctions Current Biology
Tension develops across sister kinetochores (red) upon their bipolar attachment by spindle microtubules (black line). Tension develops across sister kinetochores.
Cytoskeleton: CLASPing the end to the edge
Volume 111, Issue 5, Pages (September 2016)
Plant Development: Lessons from Getting It Twisted
Just the Beginning: Novel Functions for Angiotensin-Converting Enzymes
Volume 12, Issue 12, Pages R412-R414 (June 2002)
Ran GTPase cycle: One mechanism — two functions
Chromosome Segregation: Seeing Is Believing
Presentation transcript:

Kinetochore function: The complications of becoming attached Aaron A Van Hooser, Rebecca Heald  Current Biology  Volume 11, Issue 21, Pages R855-R857 (October 2001) DOI: 10.1016/S0960-9822(01)00515-2

Fig. 1 A diagram illustrating the components of the budding yeast kinetochore that have been implicated in microtubule attachment. The names of homologous proteins in different organisms are also given. Overlap of components denotes biochemical and/or genetic interactions. The effects of mutation or absence of a component is coded by color: red component defects cause a complete loss of chromosome attachment to the spindle; orange component defects cause monopolar attachment or loss of bipolar attachment phenotypes; and green component defects have a less severe effect, characterized by mitotic delay and/or diminished chromosome movement. Current Biology 2001 11, R855-R857DOI: (10.1016/S0960-9822(01)00515-2)