Functional genetic polymorphism of IL-1rn encoding the IL-1 receptor antagonist predicts radiographic severity of symptomatic knee OA  M. Attur, S. Ma,

Slides:



Advertisements
Similar presentations
Knee osteoarthritis radiographic progression and associations with pain and function prior to knee arthroplasty: a multicenter comparative cohort study 
Advertisements

Association of knee and ankle osteoarthritis with physical performance
Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project  A.P. Goode, A.E. Nelson,
A. Bhave, M. Mont, M. Chugthai, R. Starr  Osteoarthritis and Cartilage 
R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa 
K.S. Santangelo  Osteoarthritis and Cartilage 
Aging-related inflammation in osteoarthritis
S. Gavard  Osteoarthritis and Cartilage 
Knee joint space width progression: results of a 3
Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis  M. Chung, N. Zhao, J.B. Wong, C. Wang  Osteoarthritis.
K. A. Kimmerling, B. D. Furman, D. S. Mangiapani, M. A. Moverman, S. M
Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative  M.A. Bowes, C.B. Wolstenholme,
Sensitivity to Change of 3D Meniscal Measures in Rapidly Progressing Knee Osteoarthritis and Association With Radiographic Joint Space Width Loss  M.
Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative 
Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain  C. Ratzlaff, R. Russell, J. Duryea  Osteoarthritis.
Role of endothelin-1 in endochondral ossification and osteoarthritis
Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters  X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.
The impact of obesity on knee osteoarthritis symptoms and related biomarker profiles in a bariatric surgery cohort  J. Samuels, T. Mukherjee, E. Wilder,
Differences in radiographic features of knee osteoarthritis in African-Americans and Caucasians: the Johnston County Osteoarthritis Project  L. Braga,
Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis  S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim 
G. Venne, S. Pang, Y. Tse, R. Ellis  Osteoarthritis and Cartilage 
Change in bone area does not correlate with cartilage loss over 12 months in individuals with knee OA: Data from the osteoarthritis initiative  M.A. Bowes,
Osteoarthritis and Cartilage
Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations 
Relationship of joint hypermobility with low back pain and lumbar spine osteoarthritis: a pooled analysis of three cross-sectional studies  A.P. Goode,
Peak knee flexion and adduction moments are inversely correlated in subjects with medial compartment osteoarthritis 5 years after anterior cruciate ligament.
Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis  M. Attur, A. Statnikov,
The effect of conditional macrophage depletion on development of injury-induced knee OA in obese transgenic MAFIA mice  C.-L. Wu, J. McNeill, K. Goon,
Maintaining sufficient serum vitamin d levels over two years is associated with improved knee structural and symptomatic outcomes in people with knee.
P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B
Variation of radius of curvature around the femoral head and its associations with gender and incident radiographic hip osteoarthritis: Data from the.
Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study  J. Podlipská, P. Kaukinen,
Pain has a stronger association with thigh muscle strength than the radiographic stage of knee osteoarthritis - data from the Osteoarthritis Initiative 
Role of periostin and discoidin domain receptor-1 (DDR1) in the regulation of cartilage degeneration and expression of MMP-13  M. Attur, Q. Yang, T. Kirsch,
Y.Y. Leung, J.L. Huebner, B. Haaland, S.B.S. Wong, V.B. Kraus 
Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima 
Radiograph view influences patient selection and patient-reported outcomes in injection therapy for knee osteoarthritis  M.A. Meyer, T.S. Leroux, D.M.
S. Muraki, T. Akune, Y. En-yo, M. Yoshida, T. Suzuki, H. Yoshida, H
Two-year change in cartilage thickness on quantitative magnetic resonance imaging (qMRI) and joint space width (JSW) on X-ray demonstrate similar predictive.
M.N. Khan, M.Y. Ansari, T.M. Haqqi  Osteoarthritis and Cartilage 
N. Segal, E. Frick, M. Nevitt, J. Torner, D. Felson, A. Guermazi, D
D.D. Anderson, A.M. Kern, T.J. Stockman, C.M. Findlay, N.A. Segal 
C. -H. Chou, H. -G. Wisniewski, P. Band, J. Huebner, T. Stabler, C
Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis  M. Blagojevic, C. Jinks, A. Jeffery, K.P.
Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI  M.A. Bowes, B.T. Drew, A.C. Redmond, B.
Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells  M. Au, M. Zhu, W.-J.
Z. Huang, T. Stabler, F. Pei, V. Kraus  Osteoarthritis and Cartilage 
Osteoarthritis and Cartilage
R. L. Trevino, C. A. Pacione, S. Chubinskaya, A. -M. Malfait, M. A
Low-dose SoluMatrix meloxicam results in clinically meaningful improvements in pain in a phase 3 study of patients with osteoarthritis  R. Altman, M.
Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study  Q. Xiaofeng 
Walking with increased foot progression angle can reduce joint compression in individuals with knee OA  K. Manal, T.S. Buchanan  Osteoarthritis and Cartilage 
Individuals with severe knee OA are at increased risk of all-cause and cardiovascular disease-specific mortality: The johnston county osteoarthritis project 
Subjects with severe knee osteoarthritis reduce medio-lateral forces during gait at the expense of compressive knee contact forces  S. Meireles, F. De.
R. O. Peterson, S. R. Hoy, L. M. Vucetich, J. A. Vucetich, V. B
Osteoarthritis and Cartilage
Metabolic Syndrome and Knee Osteoarthritis
Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats  J. Hudson, M. West, Y. Fu, T. Griffin  Osteoarthritis.
Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis.
Fracture severity predicts OA risk following intra-articular fractures
Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure  C.
H. -G. Wisniewski, E. Colón, V. Liublinska, R. J. Karia, T. V
Synovitis of knee joint fat pads is correlated with inflammatory synovial cytokine profile and may have a potential role in the development of posttraumatic.
Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed  A.G. Fischer, E.M. Debbi, A. Wolf 
Triamcinolone acetonide extended-release injectable suspension (TA-ER) provides clinically relevant improvements in pain and function of knee osteoarthritis:
E. M. Debbi, B. Bernfeld, M. Falah, A. Greental, A. Sigal, R. Debi, A
Knee pain outcomes in persons discordant for radiographic hip OA: Data from the osteoarthritis initiative  G.B. Joseph, J.F. Hilton, P.M. Jungmann, J.A.
A. Carlson, B. Bothner, R. June  Osteoarthritis and Cartilage 
General Information Osteoarthritis and Cartilage
Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years  B. Antony, S. Zheng, J. Burgess,
Presentation transcript:

Functional genetic polymorphism of IL-1rn encoding the IL-1 receptor antagonist predicts radiographic severity of symptomatic knee OA  M. Attur, S. Ma, J. Samuels, S. Krasnokutsky Samuels, H. Zhou, J.T. Bencardino, M.C. Hochberg, B.D. Mitchell, V.B. Kraus, J.M. Jordan, S.B. Abramson  Osteoarthritis and Cartilage  Volume 25, Pages S210-S211 (April 2017) DOI: 10.1016/j.joca.2017.02.366 Copyright © 2017 Terms and Conditions

Figure 1 Association of radiographic medial joint space width (mJSW), age and IL-1RN haplotypes in NYU Cohorts. Osteoarthritis and Cartilage 2017 25, S210-S211DOI: (10.1016/j.joca.2017.02.366) Copyright © 2017 Terms and Conditions