Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts Yasuhiro Kotani, MD, Kozo Ishino, MD, Satoru.

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Presentation transcript:

Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts Yasuhiro Kotani, MD, Kozo Ishino, MD, Satoru Osaki, MD, Osami Honjo, MD, Takanori Suezawa, MD, Kazushige Kanki, MD, Chikao Yutani, MD, Shunji Sano, MD The Journal of Thoracic and Cardiovascular Surgery Volume 133, Issue 6, Pages 1626-1632 (June 2007) DOI: 10.1016/j.jtcvs.2007.01.068 Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Isolated myocardial perfusion. Blood cardioplegia and blood were infused into coronary arteries through aortic root cannula. MCI-186 was directly infused into coronary artery by isolated myocardial perfusion. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 1626-1632DOI: (10.1016/j.jtcvs.2007.01.068) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Changes in coronary difference in levels of malondialdehyde (MDA) between sinus and aortic root. Values are mean ± SD. The Journal of Thoracic and Cardiovascular Surgery 2007 133, 1626-1632DOI: (10.1016/j.jtcvs.2007.01.068) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Light micrographs of untreated myocardium (A) and MCI-186–treated myocardium (B) after transplantation (hematoxylin–eosin, ×40). The Journal of Thoracic and Cardiovascular Surgery 2007 133, 1626-1632DOI: (10.1016/j.jtcvs.2007.01.068) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Transmission electron micrographs of untreated myocytes (A) and MCI-186–treated myocytes (B) after transplantation (hematoxylin–eosin, ×10000). The Journal of Thoracic and Cardiovascular Surgery 2007 133, 1626-1632DOI: (10.1016/j.jtcvs.2007.01.068) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions