Fig. 2. Vascular inflammation blocks perivascular adipocyte differentiation through paracrine signals. Vascular inflammation blocks perivascular adipocyte.

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Fig. 2. Vascular inflammation blocks perivascular adipocyte differentiation through paracrine signals. Vascular inflammation blocks perivascular adipocyte differentiation through paracrine signals. (A) Experimental design of the coculture experiments in study arm 2. Human aortic tissue (Ao) from 15 patients undergoing CABG was harvested and cultured for 7 days ± angiotensin II (AngII; 100 nM). Preadipocytes isolated from PVAT around the right coronary artery (RCA) were also cultured for this period. After 7 days, the aortic tissue was washed to remove angiotensin II and was cocultured with the preadipocytes before a differentiation time course was induced. (B) IL-6, TNF-α, and IFN-γ gene expression in aortic tissue before and after stimulation with angiotensin II (n = 5 to 7 per group). (C) Quantification of oil red O in preadipocytes (control) or preadipocytes co-incubated with aortic tissue or aortic tissue prestimulated with angiotensin II (n = 6 per group). (D to F) Representative images of oil red O staining in preadipocytes co-incubated with aortic tissue as in (C). P values derived from Wilcoxon signed-rank test (B) and repeated-measures ANOVA followed by individual comparisons using paired t test (C). *P < 0.05, **P < 0.001 versus control. Alexios S. Antonopoulos et al., Sci Transl Med 2017;9:eaal2658 Published by AAAS