Satish C. Muluk, MD, David A. Vorp, PhD, Donald A

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Presentation transcript:

Enhancement of tissue factor expression by vein segments exposed to coronary arterial hemodynamics Satish C. Muluk, MD, David A. Vorp, PhD, Donald A. Severyn, MS, Susan Gleixner, BS, Peter C. Johnson, MD, Marshall W. Webster, MD Journal of Vascular Surgery Volume 27, Issue 3, Pages 521-527 (March 1998) DOI: 10.1016/S0741-5214(98)70327-1 Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Schematic of perfusion apparatus. For clarity, the pumps and the pulse duplicator apparatus are not shown. The specimen is housed inside a sterile chamber, which contains oxygenated and temperature-controlled media. The motors, carriage, and bellows are used only for coronary graft (CAVG) simulation. PP, Proximal pressure; DP, distal pressure; FG, frame grabber; MC, motion controller; A/D, analog/digital board. Journal of Vascular Surgery 1998 27, 521-527DOI: (10.1016/S0741-5214(98)70327-1) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Results of tissue factor (TF) immunohistochemical staining (original magnification, ×100) of vein segments from one experiment with HSV. A, Segment perfused under coronary artery conditions (CAVG). C, Segment perfused under venous (VEN) conditions. The upper and lower sets of panels differ only with respect to the peroxidase substrate used for staining (VIP and SG are the names assigned to these products). Horizontal arrows, positive staining on luminal side; vertical arrows, positive staining on adventitial side. Journal of Vascular Surgery 1998 27, 521-527DOI: (10.1016/S0741-5214(98)70327-1) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions