Regulatory T Cells Stay on Course

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Regulatory T Cells Stay on Course Alf Hamann Immunity Volume 36, Issue 2, Pages 161-163 (February 2012) DOI: 10.1016/j.immuni.2012.02.004 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Commitment and Differentiation of Foxp3+ Treg Cells Differentiation of Treg cells along distinct pathways might be associated with a differential degree of commitment. Thymic development appears to be characterized by early commitment, even before expression of Foxp3, and preferential adoption of a stable phenotype that is imprinted by CpG demethylation in the TSDR (CNS2). Differentiation of Foxp3+ cells in the periphery includes a larger proportion of “promiscuous Foxp3+” cells that upregulate Foxp3 without acquisition of a stable suppressive phenotype, giving rise to both “exFoxp3” cells convertible into effector cells as well as to stable, peripherally induced Treg cells. Immunity 2012 36, 161-163DOI: (10.1016/j.immuni.2012.02.004) Copyright © 2012 Elsevier Inc. Terms and Conditions