S. Borrell, S. Gagneux Clinical Microbiology and Infection

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Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis S. Borrell, S. Gagneux Clinical Microbiology and Infection Volume 17, Issue 6, Pages 815-820 (June 2011) DOI: 10.1111/j.1469-0691.2011.03556.x Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Proposed epistatic interactions in drug-resistant Mycobacterium tuberculosis complex (MTBC). Human-adapted MTBC consists of six main phylogenetic lineages. The genetic background of these strain lineages could interact differently with drug-resistance-conferring mutations. Similar interactions could occur between different drug-resistance-conferring mutations and compensatory mutations. Clinical Microbiology and Infection 2011 17, 815-820DOI: (10.1111/j.1469-0691.2011.03556.x) Copyright © 2011 European Society of Clinical Infectious Diseases Terms and Conditions