Osteoarthritis and Cartilage Brief exposure to triamcinolone acetonide, but not its continous presence, strongly inhibits cartilage regeneration by chondrocytes  I. Jansen, A. Tellegen, M. Tryfonidou, C. Öner, D. Saris, N. Woike, J. Berard, K. Messier, L. Creemers  Osteoarthritis and Cartilage  Volume 24, (April 2016) DOI: 10.1016/j.joca.2016.01.606 Copyright © 2016 Terms and Conditions

Figure 1. Chondrocytes cultured for 14 days in the continuous presence of TAA, twice 3 days exposure, or twice a 1 day exposure to 0.1 uM TAA. Effects on GAG content, release and total production, show significant reduction of GAG is due to inhibition of production * p = 0.037. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.606) Copyright © 2016 Terms and Conditions

Figure 2. COX-2 staining in pellets of chondrocytes cultured for 14 days in the continuous presence of TAA or twice a 1 day exposure to 0.1 uM TAA. No COX-2 staining was observed upon two days of exposure, wheras ample COX-2 was found in tissue regenerated in the continuous presence of TAA. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.606) Copyright © 2016 Terms and Conditions