Is oocyte meiotic spindle morphology associated with embryo ploidy

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Is oocyte meiotic spindle morphology associated with embryo ploidy Is oocyte meiotic spindle morphology associated with embryo ploidy? A prospective cohort study Liza Tilia, B.Sc., Christos Venetis, Ph.D., Suha Kilani, Ph.D., Simon Cooke, Ph.D., Michael Chapman, M.B.B.S., M.D. Fertility and Sterility Volume 105, Issue 4, Pages 1085-1092.e7 (April 2016) DOI: 10.1016/j.fertnstert.2015.12.018 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Study flow chart. Patients (n = 132) underwent PGS/D and PLM. Only patients with embryos biopsied on day 3 with conclusive results (n = 113) were included in the primary analysis. Fertility and Sterility 2016 105, 1085-1092.e7DOI: (10.1016/j.fertnstert.2015.12.018) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Polarized light microscopy images of the various types of oocyte meiotic spindles. (A) Normal, (B), dysmorphic, (C) telophase, (D) translucent, (E) no visible spindle. Fertility and Sterility 2016 105, 1085-1092.e7DOI: (10.1016/j.fertnstert.2015.12.018) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Receiver operator characteristics analyses of the capacity of embryo morphology alone and embryo morphology with spindle morphology to predict euploidy. Morphology as assessed on day 5. Fertility and Sterility 2016 105, 1085-1092.e7DOI: (10.1016/j.fertnstert.2015.12.018) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Euploidy rates according to spindle morphology and day-5 embryo quality. Error bars = 95 confidence interval. Fertility and Sterility 2016 105, 1085-1092.e7DOI: (10.1016/j.fertnstert.2015.12.018) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions