Relative protein levels

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Relative protein levels WT -/- 75 KDa ABC-me 50 KDa Actin 37 KDa 50 KDa 75 KDa 37 KDa 0.2 0.4 0.6 0.8 1 1.2 1.4 WT +/- -/- Relative protein levels (ABC-me / Porin) ND WT -/- +/- ABC-me Porin Unspecific band BCL-xL Mfrn1 WT ABC-me -/- ABC-me +/- Porin 37 KDa 0.2 0.4 0.6 0.8 1 1.2 1.4 Porin Mfrn1 BCL-xL Relative protein levels WT ABC-me +/- ABC-me -/- ND Figure S1

ABC-me -/- DAPI Caspase 3 DAPI Annexin V Figure S2

Figure S3 % change in hemoglobin levels (NAC/vehicle) WT ABC-me +/- 120 100 80 % change in hemoglobin levels (NAC/vehicle) 60 40 20 WT ABC-me +/- ABC-me -/- Figure S3

WT ABC-me +/- ABC-me -/- Figure S4 * # CD71 +++ CD71 ++ CD71 + 200 400 600 800 1000 1200 1400 1600 1800 CD71 +++ CD71 ++ CD71 + Cell population Mean Fluorescence # * Figure S4