Langerhans Cells Orchestrate TFH-Dependent Humoral Immunity

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Langerhans Cells Orchestrate TFH-Dependent Humoral Immunity Trupti Vardam, Niroshana Anandasabapathy Journal of Investigative Dermatology Volume 137, Issue 9, Pages 1826-1828 (September 2017) DOI: 10.1016/j.jid.2017.06.014 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Intradermal immunization activates epidermal Langerhans cells that present antigen to naïve CD4+ T cells in the draining lymph node leading to TFH differentiation. TFH cells are critical for generation and maintenance of germinal centers (GCs). TFH, T follicular helper. Journal of Investigative Dermatology 2017 137, 1826-1828DOI: (10.1016/j.jid.2017.06.014) Copyright © 2017 The Authors Terms and Conditions