Manu R. Varma, BS, Daria M. Moaveni, BS, Nicholas A. Dewyer, Andrea J

Slides:

Advertisements

Similar presentations

Clinical Outcomes After Varicose Vein Procedures in Octogenarians Within the Vascular Quality Initiative Varicose Vein Registry (VQI VVR) Danielle C.

Advertisements

Therapeutic angiogenesis: A comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin Todd K. Rosengart, MD, Kurt.

Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis Yunjian Zhang, PhD, MD, Hanping Shi, PhD, MD, Wenjian.

Peter W. Henderson, MD, George K

Vascular endothelial growth factor-C derived from CD11b+ cells induces therapeutic improvements in a murine model of hind limb ischemia Go Kuwahara,

Experimental pulmonary embolism: Effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin John E. Rectenwald,

Vein wall re-endothelialization after deep vein thrombosis is improved with low- molecular-weight heparin Daria K. Moaveni, MD, Erin M. Lynch, MS, Cathy.

In vivo electroporation of constitutively expressed HIF-1α plasmid DNA improves neovascularization in a mouse model of limb ischemia Geoffrey O. Ouma,

Nicos Labropoulos, PhD, DIC, RVT, Antonios P

Yi-kuan Chen, MD, Xue-mei Jiang, MSc, Jian-ping Gong, MD

Kathleen D. Gibson, MD, Brian L

National trends in venous disease

Vascular endothelial growth factor naked DNA gene transfer enhances thrombus recanalization and resolution Matthew Waltham, MA, PhD, Kevin Burnand, MS,

Staged reconstruction of the inferior vena cava after gunshot injury

Osama M. El-Sayed, BS, Nicholas A. Dewyer, MD, Catherine E

Gale Tang, MD, David N. Charo, Rong Wang, PhD, Israel F

Open surgical inferior vena cava filter retrieval for caval perforation and a novel technique for minimal cavotomy filter extraction Peter H. Connolly,

Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic.

Neovascularization in acute venous thrombosis

Pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis: Safety and feasibility study Ruth L. Bush, MD, Peter.

Clinical evaluation of suspected deep vein thrombosis guides the decision to anticoagulate prophylactically but does not impact the decision to perform.

Robert A. Brenes, MD, Caroline C

Postthrombotic vein wall remodeling: Preliminary observations

Mechanical and pharmacologic catheter-directed thrombolysis treatment of severe, symptomatic, bilateral deep vein thrombosis with congenital absence of.

Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis Yunjian Zhang, PhD, MD, Hanping Shi, PhD, MD, Wenjian.

The effect of gradual or acute arterial occlusion on skeletal muscle blood flow, arteriogenesis, and inflammation in rat hindlimb ischemia Gale L. Tang,

The effect of matrix metalloproteinase 2 and matrix metalloproteinase 2/9 deletion in experimental post-thrombotic vein wall remodeling Kristopher B.

Improving retrieval rates of temporary inferior vena cava filters

Thomas W. Wakefield, MD, Robert M

Pressure elevation slows the fibroblast response to wound healing

Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis Jose A. Diaz, MD, Nicole E. Ballard-Lipka, BS,

Journal of Vascular Surgery

Vascular endothelial growth factor naked DNA gene transfer enhances thrombus recanalization and resolution Matthew Waltham, MA, PhD, Kevin Burnand, MS,

Monocyte recruitment in venous thrombus resolution

Neuroprotection following mild hypothermia after spinal cord ischemia in rats Takeshi Saito, PhD, Shino Saito, MD, Hiroshi Yamamoto, MD, PhD, Masanori.

Inferior vena cava reconstruction using fresh inferior vena cava allograft following caval resection for leiomyosarcoma: Midterm results Marlon A. Guerrero,

Early follow-up and treatment recommendations for isolated calf deep venous thrombosis Kuldeep Singh, MD, Danny Yakoub, MD, PhD, Paul Giangola, BS, Michael.

The role of urokinase plasminogen activator and plasmin activator inhibitor-1 on vein wall remodeling in experimental deep vein thrombosis Joe F. Baldwin,

Ca2+−dependent contraction by the saponoside escin in rat vena cava: Implications in venotonic treatment of varicose veins Joseph D. Raffetto, MD, Raouf.

A depleting antibody toward sca-1 mitigates a surge of CD34+/c-kit+ progenitors and reduces vascular restenosis in a murine vascular injury model Bryan.

Therapeutic angiogenesis: A comparative study of the angiogenic potential of acidic fibroblast growth factor and heparin Todd K. Rosengart, MD, Kurt.

Agitation thrombolysis for fresh iatrogenic IVC thrombosis in patients with Budd-Chiari syndrome Peng-Xu Ding, MD, Yong-Dong Li, MD, PhD, Xin-Wei Han,

Effects of heparin, desmopressin, and isovolemic hemodilution with dextran on thrombus formation in synthetic vessel grafts inserted into the vena cava.

Nicholas H. Osborne, MD, Gilbert R. Upchurch, MD, Amit K

Inferior vena cava reconstruction with tubularized bovine pericardium

Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis Daniel.

Aortic wall cell proliferation via basic fibroblast growth factor gene transfer limits progression of experimental abdominal aortic aneurysm Katsuyuki.

The role of short-term oxygen administration in the prevention of intimal hyperplasia Charu Lata, MBBS, Derrick Green, MD, Jing Wan, MD, Sabita Roy, PhD,

Masson's tumor in the ulnar artery

Julia Humphries, MSc, Catharine L

Renal venous diversion: An unusual treatment for renal vein thrombosis

Neutropenia impairs venous thrombosis resolution in the rat

Development of a spontaneously beating vein by cardiomyocyte transplantation in the wall of the inferior vena cava in a rat: A pilot study Wangde Dai,

Deep vein thrombosis resolution is impaired in diet-induced type 2 diabetic mice Fatiha Bouzeghrane, PhD, Xiaochun Zhang, MD, BSc, Guylaine Gevry, BSc,

Unusual venous thrombosis associated with protein C deficiency

Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model Kristopher B. Deatrick, BA, Jonathan.

Ingrowth of aorta wall into stent grafts impregnated with basic fibroblast growth factor: a porcine in vivo study of blood vessel prosthesis healing

Magnetic resonance venography for the detection of deep venous thrombosis: Comparison with contrast venography and duplex Doppler ultrasonography Jeffrey.

Proximate versus nonproximate risk factor associated primary deep venous thrombosis: Clinical spectrum and outcomes Peter K. Henke, MD, Eric Ferguson,

Warfarin anticoagulation before angioplasty relieves thrombus burden in Budd-Chiari syndrome caused by inferior vena cava anatomic obstruction Tianxiao.

Surgical treatment of intact thoracoabdominal aortic aneurysms in the United States: Hospital and surgeon volume-related outcomes John A Cowan, MD, Justin.

Ruptured thoracoabdominal aortic aneurysm treatment in the United States: 1988 to 1998 John A Cowan, MD, Justin B Dimick, MD, Reid M Wainess, BS, Peter.

Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-β1 in healing rat vein grafts Randal A Wolff, PhD, Jeffrey.

Common Carotid Artery Thrombosis With Recurrent Cerebral Emboli Treated With Ligation Jacquelenn Stuhldreher, Roberto Calderon, Shahab Toursavadkohi,

Pharmacomechanical thrombectomy for iliofemoral deep vein thrombosis: An alternative in patients with contraindications to thrombolysis Atul S. Rao,

Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis.

True Radial Artery Aneurysm: Diagnosis and Treatment

Late complication from a retrievable inferior vena cava filter with associated caval, aortic, and duodenal perforation: A case report Massimiliano Veroux,

Decreased venous thrombosis with an oral inhibitor of P selectin

Vascular surgery needs millennials!

Presentation transcript:

Deep vein thrombosis resolution is not accelerated with increased neovascularization Manu R. Varma, BS, Daria M. Moaveni, BS, Nicholas A. Dewyer, Andrea J. Varga, BS, K.Barry Deatrick, BA, Steven L. Kunkel, PhD, Gilbert R. Upchurch, MD, Thomas W. Wakefield, MD, Peter K. Henke, MD Journal of Vascular Surgery Volume 40, Issue 3, Pages 536-542 (September 2004) DOI: 10.1016/j.jvs.2004.05.023

Fig 1 Neovascularization. A, Rats treated with pro-angiogenic basic fibroblast growth factor (bFGF) and epithelial neutrophil activating protein (ENA-78) had significantly more laminin-positive channels at 8 days (n = 6-8 per group; *P < .05 treatment vs controls; P < .05, 8-day vs 4-day intergroup group). B, Representative section is shown with hematoxylin counterstaining at 1000×. IP-10, Interferon inducible protein; hpf, high-power field. Journal of Vascular Surgery 2004 40, 536-542DOI: (10.1016/j.jvs.2004.05.023)

Fig 2 Laser Doppler scan. Intrathrombus blood flow (A) was greater in rats treated with basic fibroblast growth factor (bFGF), but was not affected by other compounds (n = 6-8 per group; *P < .05, treatment vs controls; P < .05, 8-day vs 4-day intergroup group). Representative laser Doppler images are shown before ligation (B), after ligation (C), at 8-day sacrifice in a control animal (D), and at 8-day sacrifice in a bFGF-treated animal (E). IP-10, Interferon inducible protein; ENA-78, epithelial neutrophil activating protein; IVC, inferior vena cava (IVC) Journal of Vascular Surgery 2004 40, 536-542DOI: (10.1016/j.jvs.2004.05.023)

Fig 3 Basic fibroblast growth factor (bFGF) concentration. bFGF was quantified with an enzyme-linked immunosorbent assay (ELISA) and normalized to total protein. Rats treated with epithelial neutrophil activating protein (ENA-78) had significantly greater intrathrombus bFGF at ELISA than control rats did at 8 days, whereas rats treated with bFGF showed a trend toward higher intrathrombus bFGF (n = 6-10 per group; *P < .05 vs 8-day controls; P < .05, 8-day vs 4-day intergroup group comparison). IP-10, Interferon inducible protein. Journal of Vascular Surgery 2004 40, 536-542DOI: (10.1016/j.jvs.2004.05.023)

Fig 4 Thrombus weight. Thrombus was weighed and measured immediately after sacrifice. There were no significant differences between any groups at the 4-day or 8-day time point. However, in all groups thrombi were smaller at the 8-day time point compared with the 4-day time point (n = 8-10 per group; *P < .05, 8-day vs 4-day intergroup group comparison). IP-10, Interferon inducible protein; bFGF, basic fibroblast growth factor; ENA-78, epithelial neutrophil activating protein. Journal of Vascular Surgery 2004 40, 536-542DOI: (10.1016/j.jvs.2004.05.023)