α-Lipoic Acid Is Ineffective as a Topical Antioxidant for Photoprotection of Skin1  Jing-Yi Lin, Fu-Hsiung Lin, James A. Burch, M. Angelica Selim, Nancy A. Monteiro-Riviere, James M. Grichnik, Sheldon R. Pinnell  Journal of Investigative Dermatology  Volume 123, Issue 5, Pages 996-998 (November 2004) DOI: 10.1111/j.0022-202X.2004.23446.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Topical α-lipoic acid is not photo protective. Colorimeter (a) and sunburn cell (b) data from untreated skin and skin treated with 5%α-lipoic acid or a commercial formulation of α lipoic acid. Journal of Investigative Dermatology 2004 123, 996-998DOI: (10.1111/j.0022-202X.2004.23446.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Topical α-lipoic acid does not supplement photoprotection provided by topica vitamins C+E. Colorimeter (a) and sunburn cell (b) data from untreated skin, skin treated with 5% vitamin C and 1% vitamin E, or skin treated with 5% vitamin C and 1% vitamin E and 5%α lipoic acid. Journal of Investigative Dermatology 2004 123, 996-998DOI: (10.1111/j.0022-202X.2004.23446.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions