Application of Biologics in IBD:

Program Overview

Treating IBD: Sprint or Marathon

Why Use a Biologic Therapy?

Treat-to-Target Concept in IBD

Mucosal Healing

Mucosal Healing (cont)

Benefits of Tight Control Management: The CALM Study

Advanced Therapy in UC, Including Biololgics

Biologic Therapy in CD

Considerations When Choosing Between Ustekinumab and Vedolizumab

Vedolizumab vs Anti-TNF Therapy in CD

Efficacy of Ustekinumab vs Placebo in CD

Safety of Anti-TNF Therapy in CD

Safety of Novel Biologic Agents in CD

Role of Biosimilars in CD

Long-Term Outcomes With CD Therapy

Immunogenicity of Biologic Therapy

Real-World Data on Vedolizumab: Persistence

Real-World Data on Vedolizumab: Mucosal Healing

Likely Future Developments in IBD

Choosing Biologics -- Key Messages

Summary

Abbreviations

Abbreviations (cont)