Friday Harbor Laboratory University of Washington August 27-31, 2006 Advanced Psychometric Workshop Composite Measures and Longitudinal Change Friday Harbor Laboratory University of Washington August 27-31, 2006 Friday Harbor Psychometrics Workshop 2006

Model Derived Cognitive Trajectories for Hypothetical Cases Friday Harbor Psychometrics Workshop 2006

Model Derived Cognitive Trajectories for Hypothetical Cases Friday Harbor Psychometrics Workshop 2006

Model Derived Cognitive Trajectories for Hypothetical Cases Friday Harbor Psychometrics Workshop 2006

Neuropsychological Test Battery MAS List Learning Test WMS-R Digit Span WMS-R Visual Span Biber Visual Learning Test Finger Tapping Test Token Test FAS Test Animal Category Fluency Boston Naming Test Benton Form Discrimination Test Mattis Dementia Rating Scale Stroop Test Friday Harbor Psychometrics Workshop 2006

Friday Harbor Psychometrics Workshop 2006

Background Neuropsychological tests of cognition are commonly used Research and clinical Advantages Standardization Measurement of areas important to brain pathologies/diseases Batteries often lengthy with many tests Friday Harbor Psychometrics Workshop 2006

Problems with Comprehensive Batteries Overwhelming numbers of variables (Mungas factor) Clinical - How do you integrate multiple, differing measures Research - How do you distill multiple results into a coherent “story” Psychometric limitations Tests may be unsuitable for longitudinal studies due to floor and ceiling effects Friday Harbor Psychometrics Workshop 2006

Mini Mental State Exam Test Characteristic Curve Friday Harbor Psychometrics Workshop 2006

Psychometrics to the Rescue Can help to identify parsimonious dimensions In conceptual/empirical context Can evaluate basic psychometric properties of measures A test is more than “reliable and valid” Can be used to create composite measures Conceptually relevant domains Desired psychometric properties Friday Harbor Psychometrics Workshop 2006

Mattis DRS Test Characteristic Curve Friday Harbor Psychometrics Workshop 2006

Global Cogn Test Characteristic Curve Friday Harbor Psychometrics Workshop 2006

Test Information Curves for Mattis Dementia Rating Scale and IRT Derived Scales Friday Harbor Psychometrics Workshop 2006

Longitudinal Analysis Longitudinal study designs have major substantive advantages in research Come at a cost Resource intensive data collection Complicated data analysis Can directly answer questions that cross sectional studies indirectly address e.g. relationship between brain change and cognitive change Friday Harbor Psychometrics Workshop 2006

Overview of Workshop Overall Theme Composite measures of cognition for longitudinal studies Psychometric methods for creating and evaluating composite measures Covariance structure analysis/structural equation modeling Item Response Theory Longitudinal analysis methods Friday Harbor Psychometrics Workshop 2006

Dataset Subcortical Ischemic Vascular Dementia Program Project Grant (AG12435) Helena Chui - PI Longitudinal neuropsychological assessment Longitudinal volumetric MRI Neuropathology Functional neuroimaging (PET) Friday Harbor Psychometrics Workshop 2006

References Mungas, D., Reed, B. R., & Kramer, J. H. (2003). Psychometrically matched measures of global cognition, memory, and executive function for assessment of cognitive decline in older persons. Neuropsychology, 17(3), 380-392. Mungas, D., Harvey, D., Reed, B. R., Jagust, W. J., DeCarli, C., Beckett, L., et al. (2005). Longitudinal volumetric MRI change and rate of cognitive decline. Neurology, 65(4), 565-571. Friday Harbor Psychometrics Workshop 2006

Schedule Sunday Evening Introduction and Overview Friday Harbor Psychometrics Workshop 2006

Schedule Monday AM Neuropsychology, neuroimaging, and dementia SIVD PPG scientific summary SIVD Overview Monday Afternoon IRT Basics Parscale Monday Evening Mplus Friday Harbor Psychometrics Workshop 2006

Schedule Tuesday AM Longitudinal analysis Overview, methods, missing data Tuesday PM SAS and Stata Tuesday Evening Mplus Friday Harbor Psychometrics Workshop 2006

Schedule Wednesday Morning Free Afternoon Workgroups Evening Workgroups, discussion Friday Harbor Psychometrics Workshop 2006

Schedule Thursday Morning Wrap-up Ferry Friday Harbor Psychometrics Workshop 2006