Volume 17, Issue 2, Pages (August 1996)

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Volume 17, Issue 2, Pages 267-274 (August 1996) Neuroanatomical Correlates of Veridical and Illusory Recognition Memory: Evidence from Positron Emission Tomography  Daniel L. Schacter, Eric Reiman, Tim Curran, Lang Sheng Yun, Dan Bandy, Kathleen B. McDermott, Henry L.Roediger Iii  Neuron  Volume 17, Issue 2, Pages 267-274 (August 1996) DOI: 10.1016/S0896-6273(00)80158-0

Figure 1 Blood Flow Increases in the Left Medial Temporal Lobe during Veridical and Illusory Word Recognition The true and false target conditions were each distinguished from the passive fixation baseline by increased blood flow in the left parahippocampal gyrus, as indicated in (a) and (b), respectively. (The true and false target conditions were also distinguished from the passive fixation baseline by significantly increased blood flow bilaterally in occipital and prefrontal regions on this section and others, which are not shown, but appear to be related to visual stimulation and decision making, respectively.) For each comparison, automated algorithms were used to characterize significant increases in regional blood flow (those with a critical z-value > 2.58, p < 0.005 uncorrected for multiple comparisons) and superimpose the increases onto an average of 12 spatially standardized brain MRIs. The section in each figure corresponds to a section 8 mm below a horizontal plane through the anterior and posterior commissures in a standard brain atlas (Talairach and Tournoux 1988). Increases in parahippocampal blood flow are shown in red, green, and blue, which correspond to z-values greater than 2.58, 2.33, and 1.64, and uncorrected probabilities less than 0.005, 0.01, and 0.05, respectively. Neuron 1996 17, 267-274DOI: (10.1016/S0896-6273(00)80158-0)

Figure 2 Blood Flow Increases in Temporoparietal Cortex Distinguish Veridical from Illusory Word Recognition The true target condition was distinguished from the true target control (a), the passive fixation baseline (data not shown), and the false target condition (b) by blood flow increases in the vicinity of the left superior temporal gyrus, temporal plane, and supramarginal gryus and by smaller increases in the right (a and b each depict all significant blood flow increases on the section displayed). In contrast, the false target condition was not distinguished from either the false target control or passive fixation condition by blood flow increases in the temporoparietal region shown in (a) and (b) (p > 0.05). For each comparison, automated algorithms were used to characterize significant increases in regional blood flow (those with a critical z-value > 2.58, p < 0.005 uncorrected for multiple comparisons) and superimpose the increases onto an average of 12 spatially standardized brain MRIs. The section in each figure corresponds to a section 20 mm above a horizontal plane through the anterior and posterior commissures in a standard brain atlas (Talairach and Tournoux 1988). Increases in temporoparietal blood flow are shown in red, green, and blue, which correspond to z-values greater than 2.58, 2.33, and 1.64, and probabilities less than 0.005, 0.01, and 0.05 uncorrected for multiple comparisons, respectively. Neuron 1996 17, 267-274DOI: (10.1016/S0896-6273(00)80158-0)