Volume 79, Issue 1, Pages (January 2011)

Slides:



Advertisements
Similar presentations
Adenosine and Tubuloglomerular Feedback in the Pathophysiology of Acute Renal Failure.
Advertisements

Renal physiology.
Volume 70, Issue 10, Pages (November 2006)
YU Yanqin, PhD Zhejiang University, School of Medicine
Tubulointerstitial Injury Associated With Chemotherapeutic Agents
New Insights Into the Pathophysiology of Renovascular Hypertension
Endothelins and inflammation: the gastrointestinal system
Blaithin A. McMahon, Patrick Thomas Murray  Kidney International 
Volume 77, Issue 10, Pages (May 2010)
Figure 4 Effects of glucagon-like peptide 1 (GLP-1) and
Role of Endothelin in the Pathogenesis of Hypertension
Volume 78, Issue 10, Pages (November 2010)
Ding Ai, John Y.-J. Shyy, Yi Zhu  Kidney International 
Shunsuke Furuta, David R.W. Jayne  Kidney International 
Prehypertension and chronic kidney disease: the ox or the plow?
The kallikrein–kinin system in diabetic nephropathy
Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation  Adriana S. Dusso  Kidney International Supplements 
John P. Middleton, Patrick H. Pun  Kidney International 
Volume 54, Issue 4, Pages (October 1998)
‘Progressive diabetic nephropathy. How useful is microalbuminuria
JAK/STAT signaling in renal diseases
The impact of cold ischemia time on renal transplant outcome
The intrarenal renin-angiotensin system in hypertension
Disparate effects of single endothelin-A and -B receptor blocker therapy on the progression of renal injury in advanced renovascular disease  Alejandro.
Volume 77, Issue 1, Pages 5-6 (January 2010)
Volume 86, Issue 4, Pages (October 2014)
Volume 70, Issue 7, Pages (October 2006)
Lipid redistribution in renal dysfunction
Filtration function in glomerulonephritis
Apoptosis and acute kidney injury
Timothy A. Sutton, Pierre C. Dagher  Kidney International 
Volume 80, Issue 8, Pages (October 2011)
Volume 70, Issue 10, Pages (November 2006)
Igor Łoniewski, Donald E. Wesson  Kidney International 
Potential role of platelet activating factor in acute renal failure
Osteopontin in diabetic nephropathy: signpost or road?
Volume 86, Issue 2, Pages (August 2014)
Modulating kidney transplant interstitial fibrosis and tubular atrophy: is the RAAS an important target?  Hatem Amer, Matthew D. Griffin  Kidney International 
Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver- derived angiotensinogen  David I. Ortiz-Melo, Robert F. Spurney 
Reduced adenosine A2a receptor–mediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration  Patrik Persson, Peter.
Impact of gender on the renal response to angiotensin II
Volume 72, Issue 2, Pages (July 2007)
Volume 74, Issue 8, Pages (October 2008)
Calcium sensing in podocytes
Volume 87, Issue 1, Pages (January 2015)
Old friends form alliance against podocytes
Tubulointerstitial damage and progression of renal failure
Volume 62, Issue 4, Pages (October 2002)
Neuronal nitric oxide synthase inhibition sensitizes the tubuloglomerular feedback mechanism after volume expansion  Russell Brown, Anna Ollerstam, A.
New drug toxicities in the onco-nephrology world
Volume 81, Issue 8, Pages (April 2012)
Volume 80, Issue 3, Pages (August 2011)
Karen A. Griffin, Anil K. Bidani  Kidney International 
Paola Romagnani, Hans-Joachim Anders  Kidney International 
Volume 71, Issue 12, Pages (June 2007)
Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
Changbin Qiu, Chris Baylis  Kidney International 
Molecular mechanisms of renal hypertrophy: Role of p27Kip1
Toshinori Aoyagi, Taka-aki Koshimizu, Akito Tanoue 
Volume 80, Issue 10, Pages (November 2011)
Volume 75, Issue 12, Pages (June 2009)
The complex field of interplay between vasoactive agents
Volume 85, Issue 3, Pages (March 2014)
Sundararaman Swaminathan, Matthew D. Griffin  Kidney International 
Volume 84, Issue 6, Pages (December 2013)
Volume 75, Issue 6, Pages (March 2009)
Temporal adaptation of tubuloglomerular feedback: Effects of COX-2
Proteinuria and hypertension with tyrosine kinase inhibitors
Renoprotection with vitamin D: Specific for diabetic nephropathy?
Christian Rask-Madsen, George L. King  Cell Metabolism 
Presentation transcript:

Volume 79, Issue 1, Pages 33-45 (January 2011) New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view  Jose M. Lopez-Novoa, Yaremi Quiros, Laura Vicente, Ana I. Morales, Francisco J. Lopez-Hernandez  Kidney International  Volume 79, Issue 1, Pages 33-45 (January 2011) DOI: 10.1038/ki.2010.337 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Mechanisms and cell signaling pathways underlying the cytotoxic effect of gentamicin. ATP, adenosine triphosphate; CaSR, extracellular calcium-sensing receptor; Cyto c, cytochrome c; ER, endoplasmic reticulum; PPARα, peroxisome proliferator-activated receptor-α; ROS, reactive oxygen species; UPR, unfolded protein response; ?, The contribution of these mechanisms to cell death is not completely known. Kidney International 2011 79, 33-45DOI: (10.1038/ki.2010.337) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 2 Glomerular effects of gentamicin. AP-1, activator protein 1; CaSR, extracellular calcium-sensing receptor; ET-1, endothelin-1; GBM, glomerular basement membrane; GFB, glomerular filtration barrier; GFR, glomerular filtration rate; HMW, high molecular weight; Kf, ultrafiltration coefficient; MMW, medium molecular weight; NO, nitric oxide; PAF, platelet activating factor; PGE2, prostaglandin E2; PLA2, phospholipase A2; RAS, renin–angiotensin system; ROS, reactive oxygen species; TXA2, thromboxane A2; ?, Unknown pathophysiological consequences. Kidney International 2011 79, 33-45DOI: (10.1038/ki.2010.337) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 3 Vascular effects of gentamicin. Ade, adenosine; ANG-II, angiotensin-II; ET-1, endothelin-1; GFR, glomerular filtration rate; Kf, ultrafiltration coefficient; PAF, platelet-activating factor; PGs, prostaglandins; ROS, reactive oxygen species; TXA2, thromboxane A2. Kidney International 2011 79, 33-45DOI: (10.1038/ki.2010.337) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 4 Integrative view of the mechanisms leading to gentamicin nephrotoxicity. It can be appreciated that, in the absence of a significant tubular obstruction, vascular and mesangial mechanisms are necessary to explain the reduction in glomerular filtration (GFR) and renal excretion, once the tubuloglomerular feedback adapts. ANG-II, angiotensin-II; ATP, adenosine triphosphate; ET-1, endothelin-1; GFR, glomerular filtration rate; Kf, ultrafiltration coefficient; ΔP, net ultrafiltration pressure; PAF, platelet-activating factor; Pt, intratubular pressure; RBF, renal blood flow. Kidney International 2011 79, 33-45DOI: (10.1038/ki.2010.337) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 5 Comparative temporal evolution of the acute kidney injury (AKI), tubular necrosis, glomerular filtration, tubuloglomerular feedback, and vascular and mesangial contraction on treatment with gentamicin. Initially, tubuloglomerular feedback (TGF) controls glomerular filtration rate. As TGF adapts, increasing tubular obstruction (TO), and vascular and mesangial contraction (VC and MC) take over and make GFR progressively lower. Kidney International 2011 79, 33-45DOI: (10.1038/ki.2010.337) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 6 Role of inflammation in the amplification of tubular, glomerular, and vascular effects of gentamicin. PAF, platelet-activating factor; RBF, renal blood flow; ROS, reactive oxygen species; TLRs, toll-like receptors. Kidney International 2011 79, 33-45DOI: (10.1038/ki.2010.337) Copyright © 2011 International Society of Nephrology Terms and Conditions