BALB/c scid mice have higher levels of macrophage-stimulating cytokines in circulation compared with BALB/c control mice. BALB/c scid mice have higher.

Slides:

Advertisements

Similar presentations

Cytokines Non-antibody proteins acting as mediators between cells, termed: Monokines – mononuclear phagocytes Lymphokines – activated T cells, especially.

Advertisements

Ahmad Shihada Silmi Hematologist & Immunologist IUG

Cytokines Prof. Dr. Zahid Shakoor M.B.B.S, Ph D (London) King Saud Univeristy.

Cytokines Prof. Dr. Zahid Shakoor M.B.B.S, Ph D (London)

Complement and Cytokines Department of Pathology

Cytokines To highlight the major cytokines that are mediators of: (i) natural immunity, (ii) adaptive immunity and (iii) hematopoesis.

1 Cluster of differentiation molecules.. 2 CELLSCD Number Macrophages, monocyte CD4, CD11b, CD64, CD115, CD86 (B7-2), CD80 (B7 – 1) Dendritic cell CD1a,

Interna tional Neurourology Journal 2015;19: Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective.

Cytokines Concept Characteristics Classification Biologic activity

Section 6 cytokines. Chapter 1 introduction introduction.

Cytokines Non-antibody proteins acting as mediators between cells, termed: Monokines – mononuclear phagocytes Lymphokines – activated T cells, especially.

Regulation of human cytokines by Cordyceps militaris

Volume 75, Issue 1, Pages (January 2010)

Innate Immune Response (Ch14)

Fig. 1. Electroporation of interleukin 12 (IL-12) DNA compared with control DNA increases the level of IL-12 expression (picograms/milligrams total protein)

2009 ProteinLounge.com IFNa IFNb IFNg Macrophage IL-1 IL-6 IL-10 IL-12

Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients Stephany P. Monsanto, M.Sc.,

The role of viruses in acute exacerbations of asthma

In vitro functional comparison of therapeutically relevant human vasculogenic progenitor cells used for cardiac cell therapy Yan Zhang, MD, MSc, Serena.

Oral and topical boswellic acid attenuates mouse osteoarthritis

NAFLD, Obesity, and Bariatric Surgery

Systemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty/stenting Kenneth DeSart, MD, Kerri O'Malley, PhD, Bradley.

Figure 1 The central role of chronic prostate

Functional Roles of Tumor Necrosis Factor-Alpha and Interleukin 1-Beta in Hypoxia and Reoxygenation Heather E. Merry, MD, Patrick Phelan, MD, Matthew.

Figure 1 Associations between baseline cerebrospinal fluid

The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: A protein array study Rachel K. Middleton, BSc,

Platelet-derived chemokines: New targets to treat liver fibrosis

Cytokines and Chemokines Chapter 6

Yiping Wang, Yuet-Ching Tay, David C.H. Harris Kidney International

Aromatase is required for female abdominal aortic aneurysm protection

Craig H Selzman, MD, Stephanie A Miller, MD, Alden H Harken, MD

Figure 4 Macrophages in liver inflammation

Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy Stephanie K. Beidler, MD, Christelle D.

Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury Ashley J. Lamparello,

Change of proinflammatory cytokines follows certain patterns after induction of endometriosis in a mouse model Qiong-Hua Chen, Ph.D., Wei-Dong Zhou,

Pg and Ec LPS induced levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Pg and Ec LPS induced levels.

Volume 87, Issue 1, Pages (January 2015)

The Immune Response to Skin Trauma Is Dependent on the Etiology of Injury in a Mouse Model of Burn and Excision Samantha M. Valvis, Jason Waithman, Fiona.

Local and systemic factors and implantation: what is the evidence?

Pro-endometriotic niche in endometriosis

Effect of Ma-Pi diet versus control diet on change in TNF-α, IL-6, CRP, BAP test, and IGF-1. Effect of Ma-Pi diet versus control diet on change in TNF-α,

Figure 1 Cytokine titers determined by the multiplex bead assay Plotted are cytokine titers (pg/mL) in CSF of patients with other noninflammatory neurologic.

Genomic and proteomic determinants of lower extremity revascularization failure: Rationale and study design Peter R. Nelson, MD, Kerri A. O’Malley, PhD,

The adipose tissue of BALB/c scid mice is quantitatively, but not qualitatively, different than that of BALB/c control mice. The adipose tissue of BALB/c.

Unstimulated levels of soluble mediators from in cultures of individuals with and without T2D with periodontitis. Unstimulated levels of soluble mediators.

(A–C) Time-course changes in morning time fasted, and daytime (A) IL-6, (B) TNF-α, and (C) β-hydroxybutyrate concentrations. (A–C) Time-course changes.

Volume 85, Issue 2, Pages (January 2014)

Holger Lawall, MD, Peter Bramlage, MD, PhD, Berthold Amann, MD

Kinetics of CXC chemokine appearance after endotoxin injection.

Supplementary Table S1. H-scores of ICAM-1, VCAM-1 and IP-10 expression in tumors of melanoma patients before and after ipilimumab or Ipi-Bev treatment.

Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction Hamood Al Kindi, MD, Arghya Paul, PhD, Zhipeng.

Combination extract inhibits immune responses in vivo.

Osteopontin in diabetic nephropathy: signpost or road?

Romain Gallet et al. BTS 2016;1:14-28

Volume 83, Issue 6, Pages (June 2013)

Kurt M. Lucin, Tony Wyss-Coray Neuron

Inflammatory stimuli increase angiopoietin-like protein 4 (ANGPTL4) gene and protein expression in human macrophages. Inflammatory stimuli increase angiopoietin-like.

(A) Serum CRP levels. (A) Serum CRP levels. T2DM: n=6 per group. *p

Lec.9 Cytokines.

Angiogenesis and arteriogenesis in limb ischemia

Pulmonary cytokine expression in C57Bl/6 mice post IT-LPS.

Mechanisms of virus-induced airway inflammation in chronic obstructive pulmonary disease (COPD). Mechanisms of virus-induced airway inflammation in chronic.

Figure 2 Effect of DMF therapy on the T helper cell repertoire and cytokine production Effect of DMF therapy on the T helper cell repertoire and cytokine.

Regulatory role of iNKT cells in T1D in humans and mice

Grethe Bergseth, BS, John D

Wolbachia-induced responses of specific cell types.

Linear associations of specific FFAs with inflammatory biomarkers.

Baseline characteristics of the participants according to study group.

Fig. 4. Plaque-associated microglia and astrocytes and brain cytokines were altered in APP/PS1;C3 KO mice compared to APP/PS1 mice. Plaque-associated microglia.

ADU-S100 primes the innate immune system in tolerant, tumor bearing neu/N mice. ADU-S100 primes the innate immune system in tolerant, tumor bearing neu/N.

Presentation transcript:

BALB/c scid mice have higher levels of macrophage-stimulating cytokines in circulation compared with BALB/c control mice. BALB/c scid mice have higher levels of macrophage-stimulating cytokines in circulation compared with BALB/c control mice. The average fold difference in the (MFI) of SCID mice relative to the average MFI of control mice (n=5). (Error bars represent the mean±SEM, and *signifies a significant difference between the control and SCID groups of p<0.05.) GCSF, granulocyte colony-stimulating factor; GMCSF, granulocyte macrophage colony-stimulating factor; GROA, growth-regulated protein alpha; IFNA, interferon alpha; IFNG interferon gamma; IL, interleukin; IP, interferon-inducible protein-10; LIX, lipopolysaccharide-inducible CXC chemokine; MCSF, macrophage colony-stimulating factor; MFI, median fluorescence intensity; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; TGFB, transforming growth factor beta; TNFA, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor. Laura L Bronsart, and Christopher H Contag BMJ Open Diab Res Care 2016;4:e000136 ©2016 by American Diabetes Association