Volume 138, Issue 1, Pages (January 2010)

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Volume 138, Issue 1, Pages 89-97 (January 2010) Phenotypic Variation of Colonic Motor Functions in Chronic Constipation Karthik Ravi, Adil E. Bharucha, Michael Camilleri, Deborah Rhoten, Timothy Bakken, Alan R. Zinsmeister Gastroenterology Volume 138, Issue 1, Pages 89-97 (January 2010) DOI: 10.1053/j.gastro.2009.07.057 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Comparison of colonic compliance (Pr50) among categories. Among patients without DD, Pr50 was lower in STC than NTC. However, among patients with DD, Pr50 was comparable in DD-NTC and DD-STC. The horizontal line is the 10th percentile value in healthy subjects. Gastroenterology 2010 138, 89-97DOI: (10.1053/j.gastro.2009.07.057) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Normal fasting, postprandial and postneostigmine tonic, and phasic colonic motor activity in a patient with STC. Observe reduced balloon volume, reflecting increased colonic tone, after a meal and after neostigmine. Manometry showed increased phasic pressure activity in the sigmoid colon after a meal and also in the descending colon after neostigmine. The principal component analysis revealed a high score for factor 2. Gastroenterology 2010 138, 89-97DOI: (10.1053/j.gastro.2009.07.057) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Impaired colonic tonic contractile responses to a meal and neostigmine in a patient with STC. In contrast, manometry revealed increased fasting and postprandial phasic pressure activity. The principal component analysis revealed a high score for factor 1. Gastroenterology 2010 138, 89-97DOI: (10.1053/j.gastro.2009.07.057) Copyright © 2010 AGA Institute Terms and Conditions