Jekyll & Hyde: Evolution of a Superfamily

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Presentation transcript:

Jekyll & Hyde: Evolution of a Superfamily Susan A. Martinis, Yan Ling Joy Pang Chemistry & Biology Volume 14, Issue 12, Pages 1307-1308 (December 2007) DOI: 10.1016/j.chembiol.2007.12.001 Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 1 Evolution of the tRNA Synthetase Superfamily Mutations confer new functions to a tRNA synthetase. Disease-causing mutations may affect either the protein synthesis activity of the tRNA synthetase or its alternate functions. Chemistry & Biology 2007 14, 1307-1308DOI: (10.1016/j.chembiol.2007.12.001) Copyright © 2007 Elsevier Ltd Terms and Conditions

Figure 2 Non-canonical activities of tRNA synthetases (A) The tRNA synthetases may be adapted for dual roles that coexist with their aminoacylation activity. (B) Paralogs of tRNA synthetases and their domains can provide important nonaminoacylation functions within the cell. Chemistry & Biology 2007 14, 1307-1308DOI: (10.1016/j.chembiol.2007.12.001) Copyright © 2007 Elsevier Ltd Terms and Conditions