MY Global view Biomedical Research in Africa as a priority Magdi Yacoub, FRS Magdi Yacoub, FRS Professcor of Cardiothoracic Surgery Heart Science Centre Harefield Imperial College London

Biomedical Research in Africa as a priority Size of the problem Multidisciplinary approach Individualised Solutions Stakeholders Strategy Benefits Challenges Solutions

Size of the problem - Massive divide in life expectancy - from 25 to 78 years.. - CNCDs accont for 60% of deaths worldwide. - CVD accounted for 16.7 million deaths in % in low and middle income countries- Loss of 148 million quality adjusted life years (QUALYs) - Huge negative economic impact. Science with Africa

The massive divide in Life Expectancy Science with Africa

Epidemiology of rheumatic heart disease 1) Aboriginal Australians (top end of Northern Territory. a. Annual incidence of RF. Of 2-7/1000 children b. Up to 7% of certain communities have established RHD (Carapitis 1998) 2) Rural Mozambique (Inharrine). Preliminary data 1 in 5 school children had RHD or EMF (A. Olga Mocumbi 2003) 3) RHD in 3963 school children in Kampur, India. 4.54/1000 (Lalchandran 2003) Science with Africa

Epidemiology (size of the problem) Hospital admissions due to RHD SCB Medical College N % 5, % 6,670 Science with Africa

Research (MYI, Imperial) Advantages of research in the Developing World 1)Develop local expertise 2)Provide opportunities for talented people 3)Realisation of the size of the problem by all concerned locally 4)Generate specific answers for local problems (neglected diseases) 1)Science technology health and wealth 2)Enhance dignity 3)Participate and contribute to global knowledge Chain of Hope UK

Multidisciplinary Research: A Tailored Approach Evidence based resource Population and Case control studies Primary and secondary prevention Basic mechanisms (cellular and molecular) Animal models Bio-engineering

Potential sustainable solutions 1)Twinning programmes 2)International programmes 3)Targeting neglected diseases 4)The concept of a tripartite research centre (epidemiology, high tech medicine and molecular) 5)NGOs joining efforts with the Government bodies 6)Creation of global network and culture of science 7)Role of individuals and universities Research (MYI, Imperial) Science with Africa

Chain of Hope UK

1 State of the art facilities for advanced research into local neglected diseases at epidemiological, cellular and molecular levels 2 Databases of heart muscle disease in Ethiopia and other African countries 3 Study genetic basis of disease in Ethiopia and Africa 4 Advanced translational research 5 Develop biotechnology 6 Education programmes and higher degrees 7 Collaborate Science Academies in Africa and worldwide 8 Advanced conference facilities Heart Research Centre Addis Ababa Objectives

Science with Africa Heart Research Centre Ground Floor Plan First Floor Plan A B VIEW BVIEW A

Total Gross External Area: 3500 SQM Level 3 Seminar facilities Level 2 Research facilities Level 1 Research facilities Level 0 Conference facilities Level -1 Storage facilities Science with Africa

The Cardiac Centre

Heart Research Institute New Cardiac Centrel Existing Dormatory Football Field Bridge to CC Science with Africa

Conclusions 1 Cardiovascular Science is essential 2 Health brings wealth 3 Many other knock on effects 4 Network of excellence, North-South & South-South collaboration 5 Engage all stakeholders (sustainability) Science with Africa