Proteasomes: Machines for All Reasons

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Proteasomes: Machines for All Reasons George N. DeMartino, Thomas G. Gillette Cell Volume 129, Issue 4, Pages 659-662 (May 2007) DOI: 10.1016/j.cell.2007.05.007 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 The Dynamic Proteasome The proteasome is composed of a 20S core and a 19S regulatory subunit (PA700). The 20S core exists in at least two forms (constitutive and immuno), which differ in the composition of the catalytic subunits located on β rings. Many regulatory proteins (ATP-independent and ATP-dependent) that bind to 20S α rings affect the functions of the 20S proteasome and determine substrate specificity. PA700 or subcomplexes of it (base or lid) may function independently of the 20S proteasome in nonproteolytic roles. Other proteins—including ubiquitin-conjugating proteins, ubiquitin-chain-binding proteins, and deubiquitylating proteins—interact with the proteasome reversibly through interactions with proteasome regulators. Cell 2007 129, 659-662DOI: (10.1016/j.cell.2007.05.007) Copyright © 2007 Elsevier Inc. Terms and Conditions